HCSGD entry for TDP1
1. General information
| Official gene symbol | TDP1 |
|---|---|
| Entrez ID | 55775 |
| Gene full name | tyrosyl-DNA phosphodiesterase 1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000012 | Single strand break repair | IDA IEA IMP | biological_process |
| GO:0003690 | Double-stranded DNA binding | IDA | molecular_function |
| GO:0003697 | Single-stranded DNA binding | IDA | molecular_function |
| GO:0004527 | Exonuclease activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006281 | DNA repair | IDA IEA | biological_process |
| GO:0006302 | Double-strand break repair | IDA | biological_process |
| GO:0008081 | Phosphoric diester hydrolase activity | IEA | molecular_function |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0017005 | 3'-tyrosyl-DNA phosphodiesterase activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9525991870 | 0.0286452262 | 0.9999902473 | 0.3216599829 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0535489360 |
| GSE13712_SHEAR | Down | -0.0402204389 |
| GSE13712_STATIC | Up | 0.1466052817 |
| GSE19018 | Up | 0.3236386136 |
| GSE19899_A1 | Down | -0.2219987618 |
| GSE19899_A2 | Down | -0.1718029907 |
| PubMed_21979375_A1 | Up | 0.0173171133 |
| PubMed_21979375_A2 | Down | -0.7497603039 |
| GSE35957 | Down | -0.4013774670 |
| GSE36640 | Down | -1.1694547449 |
| GSE54402 | Up | 0.0616243028 |
| GSE9593 | Down | -0.2694764692 |
| GSE43922 | Down | -0.4349473081 |
| GSE24585 | Down | -0.3634736208 |
| GSE37065 | Up | 0.0047974136 |
| GSE28863_A1 | Down | -0.2904072959 |
| GSE28863_A2 | Up | 0.1954608087 |
| GSE28863_A3 | Down | -0.6350874563 |
| GSE28863_A4 | Up | 0.2190738900 |
| GSE48662 | Down | -0.4841986566 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT002780 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024260 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026291 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041491 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044817 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
