HCSGD entry for CDK5RAP2

1. General information

Official gene symbolCDK5RAP2
Entrez ID55755
Gene full nameCDK5 regulatory subunit associated protein 2
Other gene symbolsC48 Cep215 MCPH3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000132Establishment of mitotic spindle orientationIEA ISSbiological_process
GO:0000226Microtubule cytoskeleton organizationIDAbiological_process
GO:0000242Pericentriolar materialIDAcellular_component
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000922Spindle poleIDAcellular_component
GO:0001578Microtubule bundle formationIDAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonNAScellular_component
GO:0005874MicrotubuleIDAcellular_component
GO:0007059Chromosome segregationIMPbiological_process
GO:0007420Brain developmentIEA ISS NASbiological_process
GO:0008017Microtubule bindingIDAmolecular_function
GO:0015631Tubulin bindingIPImolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0022008NeurogenesisISSbiological_process
GO:0030054Cell junctionIDAcellular_component
GO:0032403Protein complex bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045664Regulation of neuron differentiationNASbiological_process
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0046600Negative regulation of centriole replicationIEA ISSbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0051297Centrosome organizationIMPbiological_process
GO:0090231Regulation of spindle checkpointIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02572581590.64526695030.37576537181.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0416486275
GSE13712_SHEARDown-0.3973942619
GSE13712_STATICDown-0.2816767044
GSE19018Down-0.2545600290
GSE19899_A1Up0.6011443306
GSE19899_A2Up0.3222328730
PubMed_21979375_A1Up1.0080193671
PubMed_21979375_A2Up1.4234207098
GSE35957Down-0.7062375145
GSE36640Down-0.5203845850
GSE54402Up0.7856997723
GSE9593Down-0.3084736019
GSE43922Up0.0298080521
GSE24585Up0.0652454268
GSE37065Down-0.0949089074
GSE28863_A1Up1.0589558373
GSE28863_A2Up0.6970457565
GSE28863_A3Up0.1438554840
GSE28863_A4Up0.0491704698
GSE48662Up0.1350757205

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1301-3pMIMAT0005797MIRT035984CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042896CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045392CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.