HCSGD entry for PRKAR1B

1. General information

Official gene symbolPRKAR1B
Entrez ID5575
Gene full nameprotein kinase, cAMP-dependent, regulatory, type I, beta
Other gene symbolsPRKAR1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004862CAMP-dependent protein kinase inhibitor activityIDAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0005952CAMP-dependent protein kinase complexIEA NAScellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006468Protein phosphorylationNASbiological_process
GO:0006833Water transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007611Learning or memoryIEAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0008603CAMP-dependent protein kinase regulator activityIDA IEA NASmolecular_function
GO:0030552CAMP bindingIEAmolecular_function
GO:0034199Activation of protein kinase A activityTASbiological_process
GO:0034236Protein kinase A catalytic subunit bindingIPImolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
GO:2000480Negative regulation of cAMP-dependent protein kinase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87243932220.20353971350.99999024730.8736739726

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1196197589
GSE13712_SHEARDown-1.1503346848
GSE13712_STATICDown-0.9134493857
GSE19018Up0.0431319673
GSE19899_A1Down-0.0291460055
GSE19899_A2Up0.1564196431
PubMed_21979375_A1Up0.0392009394
PubMed_21979375_A2Up0.0087246017
GSE35957Up0.0701013891
GSE36640Down-0.0768569041
GSE54402Down-0.1835031550
GSE9593Up0.0222607734
GSE43922Up0.0537361630
GSE24585Down-0.1837090397
GSE37065Down-0.1120642277
GSE28863_A1Up0.0312424392
GSE28863_A2Up0.0334131704
GSE28863_A3Up0.1825960914
GSE28863_A4Up0.0149911726
GSE48662Up0.0064891353

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.