HCSGD entry for PARVA
1. General information
| Official gene symbol | PARVA |
|---|---|
| Entrez ID | 55742 |
| Gene full name | parvin, alpha |
| Other gene symbols | CH-ILKBP MXRA2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002040 | Sprouting angiogenesis | IEA ISS | biological_process |
| GO:0003148 | Outflow tract septum morphogenesis | IEA ISS | biological_process |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005925 | Focal adhesion | IDA IEA | cellular_component |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007163 | Establishment or maintenance of cell polarity | IEA ISS | biological_process |
| GO:0008360 | Regulation of cell shape | IEA | biological_process |
| GO:0015629 | Actin cytoskeleton | IDA | cellular_component |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0030027 | Lamellipodium | IEA | cellular_component |
| GO:0031532 | Actin cytoskeleton reorganization | IEA | biological_process |
| GO:0034113 | Heterotypic cell-cell adhesion | IEA ISS | biological_process |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
| GO:0034446 | Substrate adhesion-dependent cell spreading | IEA IMP | biological_process |
| GO:0060271 | Cilium morphogenesis | IMP | biological_process |
| GO:0070252 | Actin-mediated cell contraction | IEA ISS | biological_process |
| GO:0071670 | Smooth muscle cell chemotaxis | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9587861175 | 0.0190158277 | 0.9999902473 | 0.2707429570 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7748180483 |
| GSE13712_SHEAR | Up | 0.0297446222 |
| GSE13712_STATIC | Down | -0.1216163547 |
| GSE19018 | Down | -0.2413876044 |
| GSE19899_A1 | Down | -0.8785365575 |
| GSE19899_A2 | Down | -0.3662528212 |
| PubMed_21979375_A1 | Down | -1.0249460997 |
| PubMed_21979375_A2 | Down | -0.5165076069 |
| GSE35957 | Up | 0.4572988521 |
| GSE36640 | Up | 0.2579599213 |
| GSE54402 | Down | -0.7386409276 |
| GSE9593 | Up | 0.4610665467 |
| GSE43922 | Down | -0.3774295214 |
| GSE24585 | Up | 0.1861931131 |
| GSE37065 | Down | -0.2533781986 |
| GSE28863_A1 | Up | 0.0410319207 |
| GSE28863_A2 | Down | -0.1364503776 |
| GSE28863_A3 | Down | -0.2075575973 |
| GSE28863_A4 | Up | 0.0217425380 |
| GSE48662 | Down | -0.0929140232 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023795 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25346044 | Suppression of PINCH-2 resulted in decreased formation of the PINCH-2-IPP (PINCH-2, integrin-linked kinase and alpha-parvin) complex and reciprocally increased formation of the PINCH-1-IPP complex |
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