HCSGD entry for ENAH
1. General information
| Official gene symbol | ENAH |
|---|---|
| Entrez ID | 55740 |
| Gene full name | enabled homolog (Drosophila) |
| Other gene symbols | ENA MENA NDPP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001725 | Stress fiber | IEA | cellular_component |
| GO:0001843 | Neural tube closure | IEA | biological_process |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005925 | Focal adhesion | IDA | cellular_component |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008154 | Actin polymerization or depolymerization | IEA | biological_process |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0030027 | Lamellipodium | IEA | cellular_component |
| GO:0030054 | Cell junction | IDA | cellular_component |
| GO:0030175 | Filopodium | IEA | cellular_component |
| GO:0045202 | Synapse | IEA | cellular_component |
| GO:0046907 | Intracellular transport | IEA | biological_process |
| GO:0050699 | WW domain binding | IPI | molecular_function |
| GO:0050852 | T cell receptor signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9907312602 | 0.0014890772 | 0.9999902473 | 0.0751078394 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5804465008 |
| GSE13712_SHEAR | Down | -0.0757909526 |
| GSE13712_STATIC | Up | 0.2094054068 |
| GSE19018 | Down | -1.0590798667 |
| GSE19899_A1 | Down | -0.4190662976 |
| GSE19899_A2 | Down | -1.2300297669 |
| PubMed_21979375_A1 | Down | -1.3387964653 |
| PubMed_21979375_A2 | Down | -1.0841383265 |
| GSE35957 | Up | 0.1315323870 |
| GSE36640 | Down | -0.2251642431 |
| GSE54402 | Down | -0.9189210104 |
| GSE9593 | Down | -0.2724881612 |
| GSE43922 | Down | -0.5230657596 |
| GSE24585 | Down | -0.2548710617 |
| GSE37065 | Down | -0.3417287154 |
| GSE28863_A1 | Up | 0.5078470100 |
| GSE28863_A2 | Up | 0.0193169834 |
| GSE28863_A3 | Down | -0.5889990286 |
| GSE28863_A4 | Down | -0.5203977149 |
| GSE48662 | Down | -0.2089681914 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT016152 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-375 | MIMAT0000728 | MIRT019694 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-142-3p | MIMAT0000434 | MIRT021597 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022252 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025077 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030704 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038751 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041235 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-191-5p | MIMAT0000440 | MIRT045811 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048218 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 8866734 | Changes in En(a-) human red blood cell membranes during in vivo ageing |
| 8866734 | The human red blood cells with phenotype En(a-) were characterized by the lack of MN antigens |
| 8866734 | The red blood cells with phenotype En(a-) which were found in a Japanese family were tested to clarify the changes in membrane surfaces of the red blood cells during in vivo ageing |
| 8866734 | The contents of sialic acid, glucose, mannose, galactose, fucose, N-acetylglucosamine and N-acetylgalactosamine of the red blood cell membranes obtained from the old red blood cells with phenotype En(a-) were significantly lower than those of the young red blood cell membranes |
| 8866734 | Neither the young nor the old red blood cells with phenotype En(a-) showed the agglutination with Arachis hypogaea (PNA) which was capable of binding to T agglutinogen |
| 8866734 | It is presumed that En(a-) red blood cells are not exposed to sialidase in vivo |
| 8866734 | In comparison with the young En(a-) red blood cell membranes, the number and the distribution density of lectin receptor sites on the old ones for Limulus polyphemus (LPA), Canavalia ensiformis (Con A), Triticum vulgaris (WGA) and Bauhinia purpurea (BPA) were significantly lower |
| 8866734 | It is thought that En(a-) red blood cell ageing is accompanied by elimination of some sialoglycoconjugates which have affinity for LPA, Con A, WGA and BPA, whereas En(a-) red blood cells lack glycophorin A |
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