HCSGD entry for ATF7IP
1. General information
| Official gene symbol | ATF7IP |
|---|---|
| Entrez ID | 55729 |
| Gene full name | activating transcription factor 7 interacting protein |
| Other gene symbols | AM MCAF MCAF1 p621 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0003714 | Transcription corepressor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0006306 | DNA methylation | IDA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016887 | ATPase activity | IEA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045898 | Regulation of RNA polymerase II transcriptional preinitiation complex assembly | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2203244748 | 0.5780274686 | 0.9019175229 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0497346016 |
| GSE13712_SHEAR | Up | 0.0484303495 |
| GSE13712_STATIC | Up | 0.0495424926 |
| GSE19018 | Up | 0.3157209089 |
| GSE19899_A1 | Down | -0.1377050302 |
| GSE19899_A2 | Down | -0.4160504769 |
| PubMed_21979375_A1 | Down | -0.4765835654 |
| PubMed_21979375_A2 | Down | -0.1783689783 |
| GSE35957 | Up | 0.2217354282 |
| GSE36640 | Down | -0.0365490795 |
| GSE54402 | Down | -0.0646707034 |
| GSE9593 | Down | -0.1994777265 |
| GSE43922 | Down | -0.3608874245 |
| GSE24585 | Up | 0.1512382901 |
| GSE37065 | Up | 0.2932035685 |
| GSE28863_A1 | Up | 0.6780416272 |
| GSE28863_A2 | Up | 0.5359364814 |
| GSE28863_A3 | Down | -0.0329242110 |
| GSE28863_A4 | Up | 0.0959131498 |
| GSE48662 | Up | 0.5546333313 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-320b | MIMAT0005792 | MIRT036221 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037643 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044675 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046291 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23935871 | The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence |
| 23935871 | MCAF1 (also known as hAM or ATF7IP), a transcriptional cofactor that is overexpressed in various cancers, functions in gene activation or repression, depending on interacting partners |
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