HCSGD entry for ASF1B
1. General information
| Official gene symbol | ASF1B |
|---|---|
| Entrez ID | 55723 |
| Gene full name | anti-silencing function 1B histone chaperone |
| Other gene symbols | CIA-II |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000785 | Chromatin | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006333 | Chromatin assembly or disassembly | IEA | biological_process |
| GO:0006334 | Nucleosome assembly | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0042393 | Histone binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8830055963 | 0.0003200220 | 0.9999902473 | 0.0327754864 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5151308614 |
| GSE13712_SHEAR | Down | -0.2999115542 |
| GSE13712_STATIC | Down | -0.4426651314 |
| GSE19018 | Down | -0.2076329985 |
| GSE19899_A1 | Down | -0.2829229476 |
| GSE19899_A2 | Down | -2.4932350761 |
| PubMed_21979375_A1 | Down | -1.2883013986 |
| PubMed_21979375_A2 | Down | -2.6252130675 |
| GSE35957 | Down | -1.9785572359 |
| GSE36640 | Down | -3.5355760033 |
| GSE54402 | Down | -0.1908049126 |
| GSE9593 | Down | -1.6130858525 |
| GSE43922 | Down | -1.7617472425 |
| GSE24585 | Up | 0.5830734123 |
| GSE37065 | Down | -0.7496939992 |
| GSE28863_A1 | Down | -0.1583592436 |
| GSE28863_A2 | Up | 1.1494918773 |
| GSE28863_A3 | Up | 0.1369832900 |
| GSE28863_A4 | Up | 0.1498451627 |
| GSE48662 | Down | -0.9449347210 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016454 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029781 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-214-3p | MIMAT0000271 | MIRT035546 | Luciferase reporter assay | Functional MTI | 23100276 |
| hsa-miR-130b-5p | MIMAT0004680 | MIRT038280 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040666 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040934 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043037 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16980972 | The N- and C-terminal regions of ASF1a and ASF1b determine the different affinities of these two proteins for HIRA, by contacting regions outside the HIRA B domain |
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