HCSGD entry for PRKAG1
1. General information
| Official gene symbol | PRKAG1 |
|---|---|
| Entrez ID | 5571 |
| Gene full name | protein kinase, AMP-activated, gamma 1 non-catalytic subunit |
| Other gene symbols | AMPKG |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IDA | molecular_function |
| GO:0004679 | AMP-activated protein kinase activity | ISS | molecular_function |
| GO:0004691 | CAMP-dependent protein kinase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA ISS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006110 | Regulation of glycolysis | TAS | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006633 | Fatty acid biosynthetic process | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007283 | Spermatogenesis | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0008603 | CAMP-dependent protein kinase regulator activity | TAS | molecular_function |
| GO:0010628 | Positive regulation of gene expression | IDA | biological_process |
| GO:0016208 | AMP binding | IEA ISS | molecular_function |
| GO:0019901 | Protein kinase binding | IDA IEA | molecular_function |
| GO:0030554 | Adenyl nucleotide binding | IEA | molecular_function |
| GO:0031588 | AMP-activated protein kinase complex | IEA ISS | cellular_component |
| GO:0043531 | ADP binding | IEA ISS | molecular_function |
| GO:0045860 | Positive regulation of protein kinase activity | TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | IEA | biological_process |
| GO:0051291 | Protein heterooligomerization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2418520839 | 0.8998025151 | 0.9288540470 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0432784804 |
| GSE13712_SHEAR | Down | -0.1501241582 |
| GSE13712_STATIC | Down | -0.0576134386 |
| GSE19018 | Down | -0.0537689525 |
| GSE19899_A1 | Down | -0.1599331509 |
| GSE19899_A2 | Up | 0.1642897502 |
| PubMed_21979375_A1 | Up | 0.0096085180 |
| PubMed_21979375_A2 | Down | -0.2647648680 |
| GSE35957 | Up | 0.0267786556 |
| GSE36640 | Up | 0.2250619451 |
| GSE54402 | Up | 0.0742582344 |
| GSE9593 | Up | 0.4368487802 |
| GSE43922 | Up | 0.0978509462 |
| GSE24585 | Down | -0.0306670046 |
| GSE37065 | Down | -0.0656893715 |
| GSE28863_A1 | Up | 0.1433177920 |
| GSE28863_A2 | Up | 0.2028788914 |
| GSE28863_A3 | Up | 0.2028514230 |
| GSE28863_A4 | Up | 0.2226851309 |
| GSE48662 | Up | 0.5564680465 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022607 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023779 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037198 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045971 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
