HCSGD entry for IARS2
1. General information
| Official gene symbol | IARS2 |
|---|---|
| Entrez ID | 55699 |
| Gene full name | isoleucyl-tRNA synthetase 2, mitochondrial |
| Other gene symbols | ILERS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002161 | Aminoacyl-tRNA editing activity | IEA | molecular_function |
| GO:0004822 | Isoleucine-tRNA ligase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0006428 | Isoleucyl-tRNA aminoacylation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3618753125 | 0.2804781771 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1731674994 |
| GSE13712_SHEAR | Down | -0.0410198811 |
| GSE13712_STATIC | Up | 0.0553661683 |
| GSE19018 | Up | 1.0649972876 |
| GSE19899_A1 | Down | -0.0305055301 |
| GSE19899_A2 | Down | -0.1498743494 |
| PubMed_21979375_A1 | Up | 0.2225004474 |
| PubMed_21979375_A2 | Up | 0.4026656320 |
| GSE35957 | Down | -0.2483828296 |
| GSE36640 | Up | 0.2216430564 |
| GSE54402 | Down | -0.0777523605 |
| GSE9593 | Up | 0.1690669056 |
| GSE43922 | Down | -0.0252031429 |
| GSE24585 | Down | -0.1744075421 |
| GSE37065 | Up | 0.0852863433 |
| GSE28863_A1 | Down | -0.0152609736 |
| GSE28863_A2 | Up | 0.3753490099 |
| GSE28863_A3 | Down | -0.8655727007 |
| GSE28863_A4 | Down | -0.2956730274 |
| GSE48662 | Down | -0.0560123526 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Isoleucine | DB00167 | NUTR00031 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040636 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048072 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049747 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052088 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
