HCSGD entry for PRKACB

1. General information

Official gene symbolPRKACB
Entrez ID5567
Gene full nameprotein kinase, cAMP-dependent, catalytic, beta
Other gene symbolsPKACB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004691CAMP-dependent protein kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0005952CAMP-dependent protein kinase complexTAScellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006006Glucose metabolic processTASbiological_process
GO:0006094GluconeogenesisTASbiological_process
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006833Water transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0019433Triglyceride catabolic processTASbiological_process
GO:0031625Ubiquitin protein ligase bindingIDAmolecular_function
GO:0034199Activation of protein kinase A activityTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0051447Negative regulation of meiotic cell cycleIEAbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
GO:0097338Response to clozapineIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05581045930.65739307400.51437881651.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3148949294
GSE13712_SHEARUp0.2117220244
GSE13712_STATICUp0.0563334754
GSE19018Down-0.0828958621
GSE19899_A1Up0.2472176416
GSE19899_A2Up0.1040681686
PubMed_21979375_A1Up0.5438622499
PubMed_21979375_A2Up1.1132594789
GSE35957Down-0.0517398640
GSE36640Up1.4405217996
GSE54402Up0.2081986924
GSE9593Up0.1806127157
GSE43922Up0.6575768105
GSE24585Up0.5535198589
GSE37065Down-0.2457347718
GSE28863_A1Down-0.1928135651
GSE28863_A2Up0.1813828003
GSE28863_A3Down-0.6397024172
GSE28863_A4Down-0.1998722608
GSE48662Down-0.0537257347

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PhosphonothreonineDB02482 EXPT03092

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-93-5pMIMAT0000093MIRT027986SequencingFunctional MTI (Weak)20371350
hsa-miR-19b-3pMIMAT0000074MIRT031110SequencingFunctional MTI (Weak)20371350
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.