HCSGD entry for HIF1AN
1. General information
| Official gene symbol | HIF1AN |
|---|---|
| Entrez ID | 55662 |
| Gene full name | hypoxia inducible factor 1, alpha subunit inhibitor |
| Other gene symbols | FIH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005112 | Notch binding | IPI | molecular_function |
| GO:0005506 | Iron ion binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0016706 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | EXP | molecular_function |
| GO:0019826 | Oxygen sensor activity | NAS | molecular_function |
| GO:0031406 | Carboxylic acid binding | IDA | molecular_function |
| GO:0036138 | Peptidyl-histidine hydroxylation | IDA | biological_process |
| GO:0036139 | Peptidyl-histidine dioxygenase activity | IDA | molecular_function |
| GO:0036140 | Peptidyl-asparagine 3-dioxygenase activity | IDA IMP | molecular_function |
| GO:0042264 | Peptidyl-aspartic acid hydroxylation | IDA | biological_process |
| GO:0042265 | Peptidyl-asparagine hydroxylation | IDA IMP | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0045663 | Positive regulation of myoblast differentiation | IDA | biological_process |
| GO:0045746 | Negative regulation of Notch signaling pathway | IDA | biological_process |
| GO:0048037 | Cofactor binding | IDA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0051059 | NF-kappaB binding | IPI | molecular_function |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
| GO:0061418 | Regulation of transcription from RNA polymerase II promoter in response to hypoxia | TAS | biological_process |
| GO:0061428 | Negative regulation of transcription from RNA polymerase II promoter in response to hypoxia | IDA | biological_process |
| GO:0071456 | Cellular response to hypoxia | TAS | biological_process |
| GO:0071532 | Ankyrin repeat binding | IPI | molecular_function |
| GO:2001214 | Positive regulation of vasculogenesis | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1636279245 | 0.9602872155 | 0.8008502975 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0065718254 |
| GSE13712_SHEAR | Up | 0.1508375576 |
| GSE13712_STATIC | Up | 0.1843849417 |
| GSE19018 | Down | -0.0623919193 |
| GSE19899_A1 | Up | 0.2107377798 |
| GSE19899_A2 | Up | 0.2088411618 |
| PubMed_21979375_A1 | Up | 0.1254554428 |
| PubMed_21979375_A2 | Up | 0.7373279708 |
| GSE35957 | Down | -0.0045687333 |
| GSE36640 | Up | 0.2863425954 |
| GSE54402 | Down | -0.0106306036 |
| GSE9593 | Up | 0.1575736674 |
| GSE43922 | Up | 0.0743399981 |
| GSE24585 | Up | 0.0440117904 |
| GSE37065 | Down | -0.1479001760 |
| GSE28863_A1 | Up | 0.3698689473 |
| GSE28863_A2 | Up | 0.1397677293 |
| GSE28863_A3 | Down | -0.0991324977 |
| GSE28863_A4 | Up | 0.1160733155 |
| GSE48662 | Up | 0.0054559312 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| D-tartaric acid | DB01694 | EXPT03007 |
| N-(carboxycarbonyl)-D-phenylalanine | DB08263 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-31-5p | MIMAT0000089 | MIRT006468 | Northern blot//qRT-PCR//Western blot | Functional MTI | 22532441 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT006468 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019390 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020305 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031231 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036066 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038515 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041433 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-328-3p | MIMAT0000752 | MIRT043794 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046339 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051688 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
