HCSGD entry for PRKACA
1. General information
| Official gene symbol | PRKACA |
|---|---|
| Entrez ID | 5566 |
| Gene full name | protein kinase, cAMP-dependent, catalytic, alpha |
| Other gene symbols | PKACA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0001707 | Mesoderm formation | IEA | biological_process |
| GO:0002027 | Regulation of heart rate | TAS | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004691 | CAMP-dependent protein kinase activity | IDA IEA ISS NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005929 | Cilium | IEA | cellular_component |
| GO:0005952 | CAMP-dependent protein kinase complex | NAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006006 | Glucose metabolic process | TAS | biological_process |
| GO:0006094 | Gluconeogenesis | TAS | biological_process |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0006468 | Protein phosphorylation | NAS | biological_process |
| GO:0006833 | Water transport | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007202 | Activation of phospholipase C activity | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0010881 | Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | TAS | biological_process |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0018105 | Peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0019433 | Triglyceride catabolic process | TAS | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0031588 | AMP-activated protein kinase complex | IDA | cellular_component |
| GO:0031594 | Neuromuscular junction | IEA | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IDA | molecular_function |
| GO:0034199 | Activation of protein kinase A activity | TAS | biological_process |
| GO:0034237 | Protein kinase A regulatory subunit binding | IPI | molecular_function |
| GO:0034704 | Calcium channel complex | TAS | cellular_component |
| GO:0035584 | Calcium-mediated signaling using intracellular calcium source | TAS | biological_process |
| GO:0043393 | Regulation of protein binding | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045667 | Regulation of osteoblast differentiation | IDA | biological_process |
| GO:0046777 | Protein autophosphorylation | IEA | biological_process |
| GO:0046827 | Positive regulation of protein export from nucleus | IEA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048240 | Sperm capacitation | IEA ISS | biological_process |
| GO:0050796 | Regulation of insulin secretion | TAS | biological_process |
| GO:0050804 | Regulation of synaptic transmission | IEA | biological_process |
| GO:0051480 | Cytosolic calcium ion homeostasis | TAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0055117 | Regulation of cardiac muscle contraction | TAS | biological_process |
| GO:0060314 | Regulation of ryanodine-sensitive calcium-release channel activity | TAS | biological_process |
| GO:0061136 | Regulation of proteasomal protein catabolic process | IDA | biological_process |
| GO:0071158 | Positive regulation of cell cycle arrest | IEA ISS | biological_process |
| GO:0071333 | Cellular response to glucose stimulus | IDA | biological_process |
| GO:0071374 | Cellular response to parathyroid hormone stimulus | IEA | biological_process |
| GO:0071377 | Cellular response to glucagon stimulus | TAS | biological_process |
| GO:0071872 | Cellular response to epinephrine stimulus | TAS | biological_process |
| GO:0086064 | Cell communication by electrical coupling involved in cardiac conduction | TAS | biological_process |
| GO:0097225 | Sperm midpiece | IDA | cellular_component |
| GO:2000810 | Regulation of tight junction assembly | IDA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1011999126 | 0.6776540861 | 0.6623827492 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0742329376 |
| GSE13712_SHEAR | Down | -0.4635691900 |
| GSE13712_STATIC | Down | -0.3691472323 |
| GSE19018 | Up | 0.2200892077 |
| GSE19899_A1 | Up | 0.0635565031 |
| GSE19899_A2 | Up | 1.0104492260 |
| PubMed_21979375_A1 | Down | -0.2037803690 |
| PubMed_21979375_A2 | Down | -0.3967183315 |
| GSE35957 | Down | -0.2056949502 |
| GSE36640 | Up | 0.2593023027 |
| GSE54402 | Up | 0.1806617777 |
| GSE9593 | Down | -0.1701892771 |
| GSE43922 | Up | 0.2902183851 |
| GSE24585 | Up | 0.3269444813 |
| GSE37065 | Down | -0.3037524688 |
| GSE28863_A1 | Up | 0.1972423814 |
| GSE28863_A2 | Up | 0.2544832684 |
| GSE28863_A3 | Up | 0.0330177105 |
| GSE28863_A4 | Up | 0.0667260377 |
| GSE48662 | Up | 0.2809573776 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Entries Per Page
Displaying Page of
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-22-3p | MIMAT0000077 | MIRT030635 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037509 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042660 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043455 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-365a-3p | MIMAT0000710 | MIRT044041 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
