HCSGD entry for PRKAA2

1. General information

Official gene symbolPRKAA2
Entrez ID5563
Gene full nameprotein kinase, AMP-activated, alpha 2 catalytic subunit
Other gene symbolsAMPK AMPK2 AMPKa2 PRKAA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003682Chromatin bindingISSmolecular_function
GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityISSmolecular_function
GO:0004679AMP-activated protein kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006468Protein phosphorylationTASbiological_process
GO:0006633Fatty acid biosynthetic processIEAbiological_process
GO:0006695Cholesterol biosynthetic processIEAbiological_process
GO:0006853Carnitine shuttleTASbiological_process
GO:0006914AutophagyIEAbiological_process
GO:0006950Response to stressISSbiological_process
GO:0007050Cell cycle arrestTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008610Lipid biosynthetic processISSbiological_process
GO:0010508Positive regulation of autophagyISSbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0031669Cellular response to nutrient levelsISSbiological_process
GO:0032007Negative regulation of TOR signalingISSbiological_process
GO:0035174Histone serine kinase activityISSmolecular_function
GO:0042149Cellular response to glucose starvationISSbiological_process
GO:0042304Regulation of fatty acid biosynthetic processTASbiological_process
GO:0042593Glucose homeostasisISSbiological_process
GO:0042752Regulation of circadian rhythmISSbiological_process
GO:0043066Negative regulation of apoptotic processISSbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045821Positive regulation of glycolysisISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0047322[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activityIEAmolecular_function
GO:0048511Rhythmic processIEAbiological_process
GO:0050405[acetyl-CoA carboxylase] kinase activityIEAmolecular_function
GO:0055089Fatty acid homeostasisISSbiological_process
GO:2000505Regulation of energy homeostasisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03971389380.08631982830.44796461010.5579627210

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.7216817581
GSE13712_SHEARUp0.2746958423
GSE13712_STATICUp0.4780640037
GSE19018Up0.4112365181
GSE19899_A1Down-0.0453852472
GSE19899_A2Up0.0219358766
PubMed_21979375_A1Up1.1628000242
PubMed_21979375_A2Up0.1597367455
GSE35957Up0.3309464805
GSE36640Up0.5410939865
GSE54402Down-0.7835227563
GSE9593Up0.3976207802
GSE43922Up0.0799643163
GSE24585Up0.2285550016
GSE37065Up0.2715706018
GSE28863_A1Down-1.6602080776
GSE28863_A2Up1.1574242180
GSE28863_A3Down-0.0667040240
GSE28863_A4Down-0.8034813774
GSE48662Up0.1778159028

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-192-5pMIMAT0000222MIRT026874MicroarrayFunctional MTI (Weak)19074876
hsa-miR-98-5pMIMAT0000096MIRT027841MicroarrayFunctional MTI (Weak)19088304
hsa-miR-182-5pMIMAT0000259MIRT047217CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052107CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25484082ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis
25484082Using human nonsenescent "young" and replicative senescent endothelial cells as well as Apolipoprotein E-deficient (apoe(-/-)Arg2(+/+)) and Arg2-deficient apoe(-/-) (apoe(-/-)arg2(-/-)) mice fed a high-fat diet for 10 wk as the atherosclerotic animal model, we show here that overexpression of ARG2 in the young cells suppresses endothelial autophagy with concomitant enhanced expression of RICTOR, the essential component of the MTORC2 complex, leading to activation of the AKT-MTORC1-RPS6KB1/S6K1 (ribosomal protein S6 kinase, 70kDa, polypeptide 1) cascade and inhibition of PRKAA/AMPK (protein kinase, AMP-activated, alpha catalytic subunit)
25484082Moreover, silencing RPS6KB1 or expression of a constitutively active PRKAA prevented autophagy suppression by ARG2 or H160F
25484082In senescent cells, enhanced ARG2-RICTOR-AKT-MTORC1-RPS6KB1 and decreased PRKAA signaling and autophagy were observed, which was reversed by silencing ARG2 but not by arginase inhibitors
25484082In line with the above observations, genetic ablation of Arg2 in apoe(-/-) mice reduced RPS6KB1, enhanced PRKAA signaling and endothelial autophagy in aortas, which was associated with reduced atherosclerosis lesion formation
25484082Taken together, the results demonstrate that ARG2 impairs endothelial autophagy independently of the L-arginine ureahydrolase activity through activation of RPS6KB1 and inhibition of PRKAA, which is implicated in atherogenesis
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