HCSGD entry for SMPD4
1. General information
| Official gene symbol | SMPD4 |
|---|---|
| Entrez ID | 55627 |
| Gene full name | sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) |
| Other gene symbols | NET13 NSMASE-3 NSMASE3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0004767 | Sphingomyelin phosphodiesterase activity | TAS | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005802 | Trans-Golgi network | IDA | cellular_component |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0006685 | Sphingomyelin catabolic process | IDA | biological_process |
| GO:0006687 | Glycosphingolipid metabolic process | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046475 | Glycerophospholipid catabolic process | IDA | biological_process |
| GO:0046513 | Ceramide biosynthetic process | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050290 | Sphingomyelin phosphodiesterase D activity | IDA IEA | molecular_function |
| GO:0071356 | Cellular response to tumor necrosis factor | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9836580601 | 0.3317253296 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | Down | -0.0130471647 |
| GSE24585 | Up | 0.0446216984 |
| GSE37065 | Down | -0.2583299319 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0727391784 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Phosphatidyl serine | DB00144 | NUTR00048 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022153 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031423 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043289 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
