HCSGD entry for PRKAA1

1. General information

Official gene symbolPRKAA1
Entrez ID5562
Gene full nameprotein kinase, AMP-activated, alpha 1 catalytic subunit
Other gene symbolsAMPK AMPKa1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityNASbiological_process
GO:0001666Response to hypoxiaNASbiological_process
GO:0003682Chromatin bindingISSmolecular_function
GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004679AMP-activated protein kinase activityIDAmolecular_function
GO:0004691CAMP-dependent protein kinase activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005622IntracellularICcellular_component
GO:0005634NucleusISScellular_component
GO:0005829CytosolTAScellular_component
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006633Fatty acid biosynthetic processIEAbiological_process
GO:0006695Cholesterol biosynthetic processIEAbiological_process
GO:0006914AutophagyIEAbiological_process
GO:0006950Response to stressISSbiological_process
GO:0007050Cell cycle arrestTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008022Protein C-terminus bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008610Lipid biosynthetic processISSbiological_process
GO:0009631Cold acclimationIEAbiological_process
GO:0010508Positive regulation of autophagyISSbiological_process
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0014823Response to activityIEAbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0016324Apical plasma membraneIEAcellular_component
GO:0019395Fatty acid oxidationIEAbiological_process
GO:0019900Kinase bindingIEAmolecular_function
GO:0031000Response to caffeineIEAbiological_process
GO:0031588AMP-activated protein kinase complexISScellular_component
GO:0031669Cellular response to nutrient levelsISSbiological_process
GO:0032007Negative regulation of TOR signalingISSbiological_process
GO:0035174Histone serine kinase activityISSmolecular_function
GO:0042149Cellular response to glucose starvationISSbiological_process
GO:0042593Glucose homeostasisISSbiological_process
GO:0042752Regulation of circadian rhythmISSbiological_process
GO:0043066Negative regulation of apoptotic processISSbiological_process
GO:0045542Positive regulation of cholesterol biosynthetic processNASbiological_process
GO:0045821Positive regulation of glycolysisISSbiological_process
GO:0046318Negative regulation of glucosylceramide biosynthetic processNASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0047322[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activityIEAmolecular_function
GO:0048511Rhythmic processIEAbiological_process
GO:0050321Tau-protein kinase activityIEAmolecular_function
GO:0050405[acetyl-CoA carboxylase] kinase activityIEAmolecular_function
GO:0050995Negative regulation of lipid catabolic processISSbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0055089Fatty acid homeostasisISSbiological_process
GO:0060627Regulation of vesicle-mediated transportIEAbiological_process
GO:0070301Cellular response to hydrogen peroxideIEAbiological_process
GO:0071361Cellular response to ethanolIEAbiological_process
GO:0071456Cellular response to hypoxiaIEAbiological_process
GO:2000505Regulation of energy homeostasisISSbiological_process
GO:2001274Negative regulation of glucose import in response to insulin stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66404213370.19469996580.99999024730.8553733167

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4517502822
GSE13712_SHEARUp0.2136235348
GSE13712_STATICUp0.2026903359
GSE19018Down-0.2546599833
GSE19899_A1Up0.0068438959
GSE19899_A2Down-0.0346540134
PubMed_21979375_A1Down-0.3479272114
PubMed_21979375_A2Up0.0508106562
GSE35957Up0.2481946686
GSE36640Up0.4056568260
GSE54402Up0.0905920067
GSE9593Down-0.2726494521
GSE43922Down-0.1622459432
GSE24585Up0.5376390225
GSE37065Up0.1033174425
GSE28863_A1Down-0.1180167290
GSE28863_A2Up0.0150268639
GSE28863_A3Down-0.5277772547
GSE28863_A4Down-0.2817445929
GSE48662Down-0.0673548226

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL514409CHEMBL40459Q13131
CHEMBL535CHEMBL40459Q13131
CHEMBL535CHEMBL40459Q13131
CHEMBL1287853CHEMBL40459Q13131
CHEMBL522892CHEMBL40459Q13131
CHEMBL574738CHEMBL40459Q13131
CHEMBL296468CHEMBL40459Q13131
CHEMBL1908393CHEMBL40459Q13131
CHEMBL603469CHEMBL40459Q13131
CHEMBL162CHEMBL40459Q13131
CHEMBL162CHEMBL40459Q13131
CHEMBL608533CHEMBL40459Q13131
CHEMBL574738CHEMBL40459Q13131
CHEMBL558752CHEMBL40459Q13131
CHEMBL475251CHEMBL40459Q13131
CHEMBL1908392CHEMBL40459Q13131
CHEMBL288441CHEMBL40459Q13131
CHEMBL572878CHEMBL40459Q13131
CHEMBL1908397CHEMBL40459Q13131
CHEMBL509032CHEMBL40459Q13131
CHEMBL608533CHEMBL40459Q13131
CHEMBL558752CHEMBL40459Q13131
CHEMBL1908395CHEMBL40459Q13131
CHEMBL522892CHEMBL40459Q13131
CHEMBL572878CHEMBL40459Q13131
CHEMBL1721885CHEMBL40459Q13131
CHEMBL24828CHEMBL40459Q13131
CHEMBL1721885CHEMBL40459Q13131
CHEMBL450786CHEMBL40459Q13131
CHEMBL601719CHEMBL40459Q13131
CHEMBL191003CHEMBL40459Q13131
CHEMBL162CHEMBL40459Q13131
CHEMBL428690CHEMBL40459Q13131
CHEMBL24828CHEMBL40459Q13131
CHEMBL535CHEMBL40459Q13131
CHEMBL535CHEMBL40458Q13131
CHEMBL535CHEMBL40458Q13131
CHEMBL603469CHEMBL40458Q13131
CHEMBL608533CHEMBL40458Q13131
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  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007
PhenforminDB00914 APRD00511

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-19b-3pMIMAT0000074MIRT006742SequencingFunctional MTI (Weak)20371350
hsa-miR-148b-3pMIMAT0000759MIRT019393MicroarrayFunctional MTI (Weak)17612493
hsa-miR-130b-3pMIMAT0000691MIRT020218SequencingFunctional MTI (Weak)20371350
hsa-miR-128-3pMIMAT0000424MIRT021937MicroarrayFunctional MTI (Weak)17612493
hsa-miR-30a-5pMIMAT0000087MIRT028534ProteomicsFunctional MTI (Weak)18668040
hsa-miR-652-3pMIMAT0003322MIRT039458CLASHFunctional MTI (Weak)23622248
hsa-miR-30e-5pMIMAT0000692MIRT044135CLASHFunctional MTI (Weak)23622248
hsa-miR-29b-3pMIMAT0000100MIRT048377CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26718972The markers of cellular senescence, cell cycle proteins, and reactive oxygen species (ROS) were monitored in cultured mouse embryonic fibroblasts (MEFs) isolated from wild type (WT, C57BL/6J), AMPKalpha1, or AMPKalpha2 homozygous deficient (AMPKalpha1(-/-), AMPKalpha2(-/-)) mice by Western blot and cellular immunofluorescence staining, as well as immunohistochemistry (IHC) in skin tissue of young and aged mice
26718972Deletion of AMPKalpha2, the minor isoform of AMPKalpha, but not AMPKalpha1 in high-passaged MEFs led to spontaneous cell senescence demonstrated by accumulation of senescence-associated-beta-galactosidase (SA-beta-gal) staining and foci formation of heterochromatin protein 1 homolog gamma (HP1gamma)
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