HCSGD entry for FERMT1
1. General information
| Official gene symbol | FERMT1 |
|---|---|
| Entrez ID | 55612 |
| Gene full name | fermitin family member 1 |
| Other gene symbols | C20orf42 DTGCU2 KIND1 UNC112A URP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0005925 | Focal adhesion | IEA | cellular_component |
| GO:0007155 | Cell adhesion | IDA | biological_process |
| GO:0030054 | Cell junction | IDA | cellular_component |
| GO:0031941 | Filamentous actin | IEA | cellular_component |
| GO:0032587 | Ruffle membrane | IEA | cellular_component |
| GO:0043616 | Keratinocyte proliferation | IDA | biological_process |
| GO:0051546 | Keratinocyte migration | IDA | biological_process |
| GO:0090162 | Establishment of epithelial cell polarity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0010276851 | 0.5079894115 | 0.0864207668 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1361152122 |
| GSE13712_SHEAR | Up | 1.3818258223 |
| GSE13712_STATIC | Up | 0.8812666872 |
| GSE19018 | Down | -0.5748280087 |
| GSE19899_A1 | Up | 0.4361033470 |
| GSE19899_A2 | Up | 1.8114709617 |
| PubMed_21979375_A1 | Up | 2.3448348378 |
| PubMed_21979375_A2 | Up | 2.0617029977 |
| GSE35957 | Down | -0.1364424447 |
| GSE36640 | Down | -0.5488127982 |
| GSE54402 | Up | 2.2545790168 |
| GSE9593 | Up | 0.3446837490 |
| GSE43922 | Up | 1.3880008161 |
| GSE24585 | Down | -0.9358603194 |
| GSE37065 | Up | 0.3240027776 |
| GSE28863_A1 | Up | 0.0936726591 |
| GSE28863_A2 | Down | -0.2061364982 |
| GSE28863_A3 | Down | -0.2380439813 |
| GSE28863_A4 | Up | 0.5957595729 |
| GSE48662 | Down | -0.3294458174 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-9-5p | MIMAT0000441 | MIRT021380 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024326 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026139 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045760 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23278235 | BACKGROUND: Individuals with Kindler syndrome (KS) have loss-of-function mutations in the FERMT1 gene that encodes the focal adhesion component kindlin-1 |
| 23278235 | OBJECTIVES: To investigate how kindlin-1 deficiency affects the proliferative potential of primary human keratinocytes |
| 23278235 | In another set of experiments, kindlin-1 downregulation in normal keratinocytes was obtained by small interfering RNA (siRNA) technology |
| 23278235 | CONCLUSIONS: Our data directly implicate kindlin-1 in preventing premature senescence of keratinocytes |
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