HCSGD entry for RNPC3
1. General information
| Official gene symbol | RNPC3 |
|---|---|
| Entrez ID | 55599 |
| Gene full name | RNA-binding region (RNP1, RRM) containing 3 |
| Other gene symbols | RBM40 RNP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005689 | U12-type spliceosomal complex | IDA | cellular_component |
| GO:0006397 | MRNA processing | IEA | biological_process |
| GO:0008380 | RNA splicing | IC | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1322811291 | 0.9525591847 | 0.7376883076 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4590492429 |
| GSE13712_SHEAR | Up | 0.0493145295 |
| GSE13712_STATIC | Down | -0.0386710432 |
| GSE19018 | Up | 0.1253255600 |
| GSE19899_A1 | Up | 0.0230365893 |
| GSE19899_A2 | Up | 0.2303810662 |
| PubMed_21979375_A1 | Up | 0.2588156895 |
| PubMed_21979375_A2 | Up | 0.0240699416 |
| GSE35957 | Down | -0.2365281867 |
| GSE36640 | Up | 0.8266547300 |
| GSE54402 | Up | 0.0918068557 |
| GSE9593 | Down | -0.2943481315 |
| GSE43922 | Up | 0.1834805427 |
| GSE24585 | Up | 0.0094188974 |
| GSE37065 | Up | 0.1286139001 |
| GSE28863_A1 | Up | 0.1771066322 |
| GSE28863_A2 | Up | 0.2553191367 |
| GSE28863_A3 | Down | -0.0371789314 |
| GSE28863_A4 | Down | -0.0163593843 |
| GSE48662 | Up | 0.1335943871 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT026449 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25732822 | The 5S ribonucleoprotein particle (RNP) complex, consisting of RPL11, RPL5, and 5S rRNA, is implicated in p53 regulation under ribotoxic stress |
| 25732822 | Here, we show that the 5S RNP contributes to p53 activation and promotes cellular senescence in response to oncogenic or replicative stress |
| 24508601 | Telomerase is the ribonucleoprotein (RNP) reverse transcriptase responsible for synthesizing the 3' ends of linear chromosomes |
| 24508601 | Together these studies provide the first glimpse into the organization of the proteins and RNA in the telomerase RNP |
| 11780638 | Our results identify the Cajal body as a potential site of telomerase RNP biogenesis |
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