HCSGD entry for SOX6

1. General information

Official gene symbolSOX6
Entrez ID55553
Gene full nameSRY (sex determining region Y)-box 6
Other gene symbolsHSSOX6 SOXD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000902Cell morphogenesisIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0003677DNA bindingNASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA NAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0007517Muscle organ developmentNASbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0016458Gene silencingIEAbiological_process
GO:0021778Oligodendrocyte cell fate specificationIEAbiological_process
GO:0032332Positive regulation of chondrocyte differentiationIDA IEAbiological_process
GO:0035051Cardiocyte differentiationIEAbiological_process
GO:0042692Muscle cell differentiationIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIEAmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048708Astrocyte differentiationIEAbiological_process
GO:0048821Erythrocyte developmentIEAbiological_process
GO:0051216Cartilage developmentIEAbiological_process
GO:0061036Positive regulation of cartilage developmentIDAbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIDAbiological_process
GO:2000741Positive regulation of mesenchymal stem cell differentiationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57619380340.11940663730.99999024730.6639379143

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0073160064
GSE13712_SHEARDown-0.0779376174
GSE13712_STATICDown-0.0702099286
GSE19018Down-0.0334412055
GSE19899_A1Down-0.1683238018
GSE19899_A2Down-1.2165660092
PubMed_21979375_A1Down-1.2025710882
PubMed_21979375_A2Down-0.5748085933
GSE35957Up0.0985482083
GSE36640Up1.0262886048
GSE54402Down-0.6109429005
GSE9593Down-0.0830567897
GSE43922Down-0.4846668676
GSE24585Up0.3452994920
GSE37065Up0.4864426631
GSE28863_A1Down-0.0778120198
GSE28863_A2Down-0.1048584721
GSE28863_A3Up0.1966546839
GSE28863_A4Up0.0566251002
GSE48662Up0.5997898161

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT003203Luciferase reporter assayFunctional MTI20081117
hsa-miR-499b-5pMIMAT0019897MIRT004658Luciferase reporter assayFunctional MTI20081117
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.