HCSGD entry for SMPD3

1. General information

Official gene symbolSMPD3
Entrez ID55512
Gene full namesphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Other gene symbolsNSMASE2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000137Golgi cis cisternaIEAcellular_component
GO:0000139Golgi membraneIEAcellular_component
GO:0004767Sphingomyelin phosphodiesterase activityIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006665Sphingolipid metabolic processTASbiological_process
GO:0006684Sphingomyelin metabolic processIEAbiological_process
GO:0006685Sphingomyelin catabolic processTASbiological_process
GO:0006687Glycosphingolipid metabolic processTASbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0030072Peptide hormone secretionIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.59075290830.89295835640.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0566693759
GSE13712_SHEARDown-0.0504641581
GSE13712_STATICUp0.0087028602
GSE19018Up0.1318295838
GSE19899_A1Down-0.0356179037
GSE19899_A2Up0.0341961636
PubMed_21979375_A1Down-0.2296050674
PubMed_21979375_A2Up0.0883408909
GSE35957Down-0.0251079854
GSE36640Up0.0101896762
GSE54402Up0.0407975402
GSE9593Down-0.0640140678
GSE43922Up0.0297834587
GSE24585Up0.3423894097
GSE37065Down-0.1469300952
GSE28863_A1Up0.0071660974
GSE28863_A2Up0.1844047645
GSE28863_A3Up0.1690129697
GSE28863_A4Up0.1150679778
GSE48662Up0.0244303189

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Phosphatidyl serineDB00144 NUTR00048

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT028920MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.