HCSGD entry for MCM10
1. General information
| Official gene symbol | MCM10 |
|---|---|
| Entrez ID | 55388 |
| Gene full name | minichromosome maintenance complex component 10 |
| Other gene symbols | CNA43 DNA43 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006260 | DNA replication | IEA TAS | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9796497132 | 0.0000898826 | 0.9999902473 | 0.0162623288 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4022376813 |
| GSE13712_SHEAR | Up | 0.0537561851 |
| GSE13712_STATIC | Down | -0.0288657820 |
| GSE19018 | Down | -0.3856905719 |
| GSE19899_A1 | Down | -0.7735732070 |
| GSE19899_A2 | Down | -4.5475038848 |
| PubMed_21979375_A1 | Down | -2.6766381297 |
| PubMed_21979375_A2 | Down | -4.3269968621 |
| GSE35957 | Down | -2.1087885504 |
| GSE36640 | Down | -4.0842117909 |
| GSE54402 | Down | -0.4277842894 |
| GSE9593 | Down | -1.8888369891 |
| GSE43922 | Down | -2.0766923501 |
| GSE24585 | Down | -0.1449421143 |
| GSE37065 | Down | -0.3337786002 |
| GSE28863_A1 | Down | -0.1828328725 |
| GSE28863_A2 | Up | 0.3655787290 |
| GSE28863_A3 | Down | -0.0257910800 |
| GSE28863_A4 | Up | 0.3407569091 |
| GSE48662 | Down | -0.6700143572 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT004854 | Luciferase reporter assay//qRT-PCR//Reporter assay;Microarray;Other | Functional MTI | 19074876 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016315 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016315 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019273 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024276 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030381 | qRT-PCR;Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038395 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039760 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT047354 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-146a-5p | MIMAT0000449 | NA | hsa-miR-146a | 19944095 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21160097 | There are also MCM1 and MCM10, which are important in DNA replication, but they do not possess the specific MCM box |
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