HCSGD entry for PPT1

1. General information

Official gene symbolPPT1
Entrez ID5538
Gene full namepalmitoyl-protein thioesterase 1
Other gene symbolsCLN1 INCL PPT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002084Protein depalmitoylationIDA IEA ISSbiological_process
GO:0005576Extracellular regionIDA ISScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005764LysosomeIDA IEA ISScellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolISScellular_component
GO:0006309Apoptotic DNA fragmentationIDAbiological_process
GO:0006464Cellular protein modification processIEAbiological_process
GO:0006898Receptor-mediated endocytosisIMPbiological_process
GO:0006907PinocytosisIMPbiological_process
GO:0007040Lysosome organizationIEAbiological_process
GO:0007042Lysosomal lumen acidificationIMPbiological_process
GO:0007269Neurotransmitter secretionIEAbiological_process
GO:0007399Nervous system developmentIMPbiological_process
GO:0007420Brain developmentIMPbiological_process
GO:0007601Visual perceptionIEAbiological_process
GO:0007625Grooming behaviorIEAbiological_process
GO:0008021Synaptic vesicleIDA IEAcellular_component
GO:0008306Associative learningIEAbiological_process
GO:0008344Adult locomotory behaviorIEAbiological_process
GO:0008474Palmitoyl-(protein) hydrolase activityIDA IEA IMP ISSmolecular_function
GO:0015031Protein transportIMPbiological_process
GO:0016042Lipid catabolic processIDAbiological_process
GO:0016290Palmitoyl-CoA hydrolase activityIDA ISSmolecular_function
GO:0030149Sphingolipid catabolic processTASbiological_process
GO:0030163Protein catabolic processNASbiological_process
GO:0030308Negative regulation of cell growthIMPbiological_process
GO:0030424AxonIDA IEAcellular_component
GO:0030425DendriteIEAcellular_component
GO:0031579Membrane raft organizationIMPbiological_process
GO:0032429Regulation of phospholipase A2 activityIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIMPbiological_process
GO:0044257Cellular protein catabolic processIEAbiological_process
GO:0045121Membrane raftIDAcellular_component
GO:0048260Positive regulation of receptor-mediated endocytosisIMPbiological_process
GO:0048549Positive regulation of pinocytosisIMPbiological_process
GO:0048666Neuron developmentTASbiological_process
GO:0050803Regulation of synapse structure and activityNASbiological_process
GO:0051181Cofactor transportIMPbiological_process
GO:0051186Cofactor metabolic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.70638369740.05364397250.99999024730.4366976529

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3399124428
GSE13712_SHEARDown-0.3978348317
GSE13712_STATICDown-0.1912242780
GSE19018Up0.0864637906
GSE19899_A1Up0.0141313805
GSE19899_A2Up0.1061560613
PubMed_21979375_A1Up0.2874317010
PubMed_21979375_A2Up0.0897741843
GSE35957Down-0.6125761775
GSE36640Down-0.7236611323
GSE54402Down-0.0630902165
GSE9593Down-0.3874921975
GSE43922Up0.3099020911
GSE24585Up0.0613032561
GSE37065Up0.3468910178
GSE28863_A1Down-0.0905106170
GSE28863_A2Up0.8832447015
GSE28863_A3Down-0.8311347644
GSE28863_A4Down-0.3216857158
GSE48662Down-0.4701377093

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

1-Hexadecylsulfonyl FluorideDB02035 EXPT01783
Palmitic AcidDB03796 EXPT01393 | EXPT02607

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029493MicroarrayFunctional MTI (Weak)19088304
hsa-miR-16-5pMIMAT0000069MIRT031707ProteomicsFunctional MTI (Weak)18668040
hsa-miR-339-5pMIMAT0000764MIRT042764CLASHFunctional MTI (Weak)23622248
hsa-miR-29c-3pMIMAT0000681MIRT044242CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044818CLASHFunctional MTI (Weak)23622248
hsa-miR-15b-5pMIMAT0000417MIRT046542CLASHFunctional MTI (Weak)23622248
hsa-miR-29a-3pMIMAT0000086MIRT049981CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18847333ERalpha agonist propylpyrazoletriol (PPT) and ERbeta agonist diarylpropionitrile (DPN) attenuated EtOH-induced ERalpha and ERbeta gene overexpression, respectively
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