HCSGD entry for HJURP
1. General information
| Official gene symbol | HJURP |
|---|---|
| Entrez ID | 55355 |
| Gene full name | Holliday junction recognition protein |
| Other gene symbols | FAKTS URLC9 hFLEG1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000775 | Chromosome, centromeric region | IDA | cellular_component |
| GO:0000777 | Condensed chromosome kinetochore | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006334 | Nucleosome assembly | TAS | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007059 | Chromosome segregation | IMP | biological_process |
| GO:0034080 | CENP-A containing nucleosome assembly at centromere | IMP TAS | biological_process |
| GO:0042393 | Histone binding | IDA IPI | molecular_function |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043254 | Regulation of protein complex assembly | IDA | biological_process |
| GO:0051101 | Regulation of DNA binding | IDA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9450020098 | 0.0000206527 | 0.9999902473 | 0.0084212121 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5286852541 |
| GSE13712_SHEAR | Down | -0.5005163561 |
| GSE13712_STATIC | Down | -0.5250735936 |
| GSE19018 | Up | 0.0754610014 |
| GSE19899_A1 | Down | -0.9808145147 |
| GSE19899_A2 | Down | -4.6269493261 |
| PubMed_21979375_A1 | Down | -3.0715660462 |
| PubMed_21979375_A2 | Down | -6.0371185446 |
| GSE35957 | Down | -3.9218044732 |
| GSE36640 | Down | -4.3347567925 |
| GSE54402 | Down | -1.0253200478 |
| GSE9593 | Down | -1.2044667767 |
| GSE43922 | Down | -1.3198911568 |
| GSE24585 | Up | 0.2671938378 |
| GSE37065 | Down | -0.4827053943 |
| GSE28863_A1 | Down | -0.2671438399 |
| GSE28863_A2 | Up | 0.9179225320 |
| GSE28863_A3 | Up | 0.0446663747 |
| GSE28863_A4 | Up | 0.0575804017 |
| GSE48662 | Down | -2.6955809166 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024443 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026468 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-671-5p | MIMAT0003880 | MIRT039300 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23292286 | Holliday junction recognition protein (HJURP), a centromere protein-A (CENP-A) histone chaperone, mediates centromere-specific assembly of CENP-A nucleosome, contributing to high-fidelity chromosome segregation during cell division |
| 23292286 | We found that the expression levels of HJURP decreased in human dermal fibroblasts and umbilical vein endothelial cells in replicative or premature senescence |
| 23292286 | Ectopic expression of HJURP in senescent cells partially overcame cell senescence |
| 23292286 | Conversely, downregulation of HJURP in young cells led to premature senescence |
| 23292286 | These data suggest that HJURP plays an important role in the regulation of cellular senescence through a p53-dependent pathway and might contribute to tissue or organismal aging and protection of cellular transformation |
Entries Per Page
Displaying Page of
