HCSGD entry for RNLS
1. General information
| Official gene symbol | RNLS |
|---|---|
| Entrez ID | 55328 |
| Gene full name | renalase, FAD-dependent amine oxidase |
| Other gene symbols | C10orf59 RENALASE |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002931 | Response to ischemia | IEA | biological_process |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0071871 | Response to epinephrine | IEA | biological_process |
| GO:1902074 | Response to salt | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9361354166 | 0.0658728810 | 0.9999902473 | 0.4844481978 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1314236641 |
| GSE13712_SHEAR | Up | 0.0208215213 |
| GSE13712_STATIC | Up | 0.1945610498 |
| GSE19018 | Down | -0.4654748618 |
| GSE19899_A1 | Down | -0.2082978693 |
| GSE19899_A2 | Down | -0.3098864302 |
| PubMed_21979375_A1 | Up | 0.1535460155 |
| PubMed_21979375_A2 | Down | -0.4612959060 |
| GSE35957 | Up | 0.0013388541 |
| GSE36640 | Up | 0.3315465099 |
| GSE54402 | Down | -0.4438517424 |
| GSE9593 | Up | 0.1409987077 |
| GSE43922 | Down | -0.6570652350 |
| GSE24585 | Down | -0.0923552875 |
| GSE37065 | Down | -0.0022037538 |
| GSE28863_A1 | Up | 0.0283479451 |
| GSE28863_A2 | Down | -0.1292555233 |
| GSE28863_A3 | Up | 0.0101537532 |
| GSE28863_A4 | Up | 0.1048613622 |
| GSE48662 | Down | -0.5439002193 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26972355 | Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer |
| 26972355 | Renalase, a recently discovered secreted flavoprotein, provides cytoprotection against ischemic and toxic cellular injury by signaling through the PI3K-AKT and MAPK pathways |
| 26972355 | Here we show that renalase expression is increased in pancreatic cancer tissue and that it functions as a growth factor |
| 26972355 | In a cohort of patients with pancreatic ductal adenocarcinoma, overall survival was inversely correlated with renalase expression in the tumor mass, suggesting a pathogenic role for renalase |
| 26972355 | Inhibition of renalase signaling using siRNA or inhibitory anti-renalase antibodies decreased the viability of cultured pancreatic ductal adenocarcinoma cells |
| 26972355 | In two xenograft mouse models, either the renalase monoclonal antibody m28-RNLS or shRNA knockdown of renalase inhibited pancreatic ductal adenocarcinoma growth |
| 26972355 | Inhibition of renalase caused tumor cell apoptosis and cell cycle arrest |
| 26972355 | These results reveal a previously unrecognized role for the renalase in cancer: its expression may serve as a prognostic maker and its inhibition may provide an attractive therapeutic target in pancreatic cancer |
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