HCSGD entry for PPP4C
1. General information
| Official gene symbol | PPP4C |
|---|---|
| Entrez ID | 5531 |
| Gene full name | protein phosphatase 4, catalytic subunit |
| Other gene symbols | PP4 PP4C PPH3 PPP4 PPX |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004704 | NF-kappaB-inducing kinase activity | NAS | molecular_function |
| GO:0004721 | Phosphoprotein phosphatase activity | IEA | molecular_function |
| GO:0004722 | Protein serine/threonine phosphatase activity | IDA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | NAS | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0008152 | Metabolic process | IDA NAS | biological_process |
| GO:0010569 | Regulation of double-strand break repair via homologous recombination | IMP | biological_process |
| GO:0016310 | Phosphorylation | NAS | biological_process |
| GO:0016311 | Dephosphorylation | IDA NAS | biological_process |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0023014 | Signal transduction by phosphorylation | NAS | biological_process |
| GO:0030289 | Protein phosphatase 4 complex | IEA | cellular_component |
| GO:0035556 | Intracellular signal transduction | NAS | biological_process |
| GO:0038061 | NIK/NF-kappaB signaling | NAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0666823221 | 0.5788813115 | 0.5561771863 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5169035631 |
| GSE13712_SHEAR | Up | 0.1827389328 |
| GSE13712_STATIC | Up | 0.0078674848 |
| GSE19018 | Up | 0.2615259159 |
| GSE19899_A1 | Down | -0.0029140318 |
| GSE19899_A2 | Up | 0.7532972600 |
| PubMed_21979375_A1 | Up | 0.7578821479 |
| PubMed_21979375_A2 | Up | 0.2629087249 |
| GSE35957 | Down | -0.3220361145 |
| GSE36640 | Down | -0.1803356653 |
| GSE54402 | Up | 0.8465233064 |
| GSE9593 | Up | 0.0033030893 |
| GSE43922 | Up | 0.0491194593 |
| GSE24585 | Down | -0.2278437585 |
| GSE37065 | Down | -0.2643448758 |
| GSE28863_A1 | Down | -0.1366016588 |
| GSE28863_A2 | Down | -0.2922382245 |
| GSE28863_A3 | Down | -0.3974376426 |
| GSE28863_A4 | Up | 0.2275411578 |
| GSE48662 | Up | 0.5315008275 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027866 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036330 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039997 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044311 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044391 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045687 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049792 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
