HCSGD entry for SPTLC3
1. General information
| Official gene symbol | SPTLC3 |
|---|---|
| Entrez ID | 55304 |
| Gene full name | serine palmitoyltransferase, long chain base subunit 3 |
| Other gene symbols | C20orf38 LCB2B LCB3 SPT3 SPTLC2L dJ718P11 dJ718P11.1 hLCB2b |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004758 | Serine C-palmitoyltransferase activity | IDA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0008483 | Transaminase activity | IEA | molecular_function |
| GO:0009058 | Biosynthetic process | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0017059 | Serine C-palmitoyltransferase complex | IDA | cellular_component |
| GO:0030148 | Sphingolipid biosynthetic process | TAS | biological_process |
| GO:0030170 | Pyridoxal phosphate binding | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046520 | Sphingoid biosynthetic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6393263478 | 0.0503126819 | 0.9999902473 | 0.4201841104 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0248971420 |
| GSE13712_SHEAR | Down | -0.8727919714 |
| GSE13712_STATIC | Down | -0.3984910332 |
| GSE19018 | Up | 0.3600711107 |
| GSE19899_A1 | Up | 0.0284266381 |
| GSE19899_A2 | Down | -0.4268462537 |
| PubMed_21979375_A1 | Down | -0.3216453375 |
| PubMed_21979375_A2 | Down | -0.1100578774 |
| GSE35957 | Down | -0.3153970848 |
| GSE36640 | Down | -0.5160477858 |
| GSE54402 | Down | -0.3681576854 |
| GSE9593 | Up | 0.2788199898 |
| GSE43922 | Down | -1.3949313765 |
| GSE24585 | Up | 0.1226794869 |
| GSE37065 | Up | 0.3766123994 |
| GSE28863_A1 | Up | 0.5865680799 |
| GSE28863_A2 | Up | 0.1474611246 |
| GSE28863_A3 | Down | -0.0445386458 |
| GSE28863_A4 | Down | -0.0735127537 |
| GSE48662 | Down | -0.1714335754 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT030899 | Microarray | Functional MTI (Weak) | 18591254 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
