HCSGD entry for FBXW7
1. General information
| Official gene symbol | FBXW7 |
|---|---|
| Entrez ID | 55294 |
| Gene full name | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase |
| Other gene symbols | AGO CDC4 FBW6 FBW7 FBX30 FBXO30 FBXW6 SEL-10 SEL10 hAgo hCdc4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001570 | Vasculogenesis | IEA | biological_process |
| GO:0001944 | Vasculature development | TAS | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | IDA TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0007062 | Sister chromatid cohesion | IMP | biological_process |
| GO:0007219 | Notch signaling pathway | IEA TAS | biological_process |
| GO:0010868 | Negative regulation of triglyceride biosynthetic process | ISS | biological_process |
| GO:0010883 | Regulation of lipid storage | ISS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0019005 | SCF ubiquitin ligase complex | IDA | cellular_component |
| GO:0030324 | Lung development | IEA | biological_process |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0032876 | Negative regulation of DNA endoreduplication | IMP | biological_process |
| GO:0032880 | Regulation of protein localization | ISS | biological_process |
| GO:0034644 | Cellular response to UV | IDA | biological_process |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0045741 | Positive regulation of epidermal growth factor-activated receptor activity | IDA | biological_process |
| GO:0045746 | Negative regulation of Notch signaling pathway | ISS | biological_process |
| GO:0050821 | Protein stabilization | IDA | biological_process |
| GO:0055088 | Lipid homeostasis | ISS | biological_process |
| GO:0070374 | Positive regulation of ERK1 and ERK2 cascade | IMP | biological_process |
| GO:2000060 | Positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:2000346 | Negative regulation of hepatocyte proliferation | ISS | biological_process |
| GO:2000639 | Negative regulation of SREBP signaling pathway | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4348543368 | 0.4044073212 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2930304935 |
| GSE13712_SHEAR | Down | -0.1382790172 |
| GSE13712_STATIC | Up | 0.1486565353 |
| GSE19018 | Down | -0.1213632981 |
| GSE19899_A1 | Down | -0.0140256617 |
| GSE19899_A2 | Up | 0.0951528327 |
| PubMed_21979375_A1 | Down | -0.2316280386 |
| PubMed_21979375_A2 | Up | 0.4387077213 |
| GSE35957 | Up | 0.3779404578 |
| GSE36640 | Up | 0.2404641171 |
| GSE54402 | Down | -0.1491934301 |
| GSE9593 | Down | -0.0634403981 |
| GSE43922 | Up | 0.0835285412 |
| GSE24585 | Up | 0.1698116163 |
| GSE37065 | Up | 0.2519074396 |
| GSE28863_A1 | Down | -0.2540861582 |
| GSE28863_A2 | Down | -0.5521304578 |
| GSE28863_A3 | Down | -0.3955267973 |
| GSE28863_A4 | Down | -0.1853597616 |
| GSE48662 | Up | 0.1411384456 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-27a-3p | MIMAT0000084 | MIRT006357 | Luciferase reporter assay//Western blot | Functional MTI | 21460851 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT006357 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-223-3p | MIMAT0000280 | MIRT006237 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22270966 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT003827 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-107 | MIMAT0000104 | MIRT004756 | Luciferase reporter assay//Microarray//Northern blot//Western blot | Functional MTI | 20042474 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT004757 | Luciferase reporter assay//Microarray//Northern blot//Western blot | Functional MTI | 20042474 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT004757 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-590-3p | MIMAT0004801 | MIRT016198 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027232 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027385 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT032006 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-223-3p | MIMAT0000280 | NA | hsa-miR-223 | {Western blot} | {overexpression} | {FLAG} | 20826802 |
| hsa-miR-25-3p | MIMAT0000081 | NA | hsa-miR-25 | {Western blot} | {overexpression} | {FLAG} | 20826802 |
| hsa-miR-27a-3p | MIMAT0000084 | 1 | hsa-miR-27a | {Western blot} | {overexpression by miRNA mimics tranfection} | 21460851 | |
| hsa-miR-27a-3p | MIMAT0000084 | 2 | hsa-miR-27a | {Western blot} | {overexpression by miRNA mimics tranfection} | 21460851 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
