HCSGD entry for ADI1
1. General information
| Official gene symbol | ADI1 |
|---|---|
| Entrez ID | 55256 |
| Gene full name | acireductone dioxygenase 1 |
| Other gene symbols | APL1 ARD Fe-ARD MTCBP1 Ni-ARD SIPL mtnD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000096 | Sulfur amino acid metabolic process | TAS | biological_process |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006595 | Polyamine metabolic process | TAS | biological_process |
| GO:0010309 | Acireductone dioxygenase [iron(II)-requiring] activity | IEA TAS | molecular_function |
| GO:0016491 | Oxidoreductase activity | IDA | molecular_function |
| GO:0019509 | L-methionine salvage from methylthioadenosine | IDA IEA TAS | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9637620151 | 0.0260206489 | 0.9999902473 | 0.3090656588 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4839424487 |
| GSE13712_SHEAR | Down | -0.0133120693 |
| GSE13712_STATIC | Down | -0.3696953767 |
| GSE19018 | Up | 0.1596298468 |
| GSE19899_A1 | Down | -1.1577880316 |
| GSE19899_A2 | Down | -0.4062837619 |
| PubMed_21979375_A1 | Down | -0.9249202141 |
| PubMed_21979375_A2 | Down | -0.5632431771 |
| GSE35957 | Up | 0.2017777282 |
| GSE36640 | Down | -0.0386423640 |
| GSE54402 | Down | -0.3486111713 |
| GSE9593 | Up | 0.0377317595 |
| GSE43922 | Down | -0.5356321653 |
| GSE24585 | Down | -0.1337986693 |
| GSE37065 | Down | -0.0793990178 |
| GSE28863_A1 | Down | -0.1024440711 |
| GSE28863_A2 | Down | -0.0120077293 |
| GSE28863_A3 | Down | -0.3895224562 |
| GSE28863_A4 | Down | -0.0463885818 |
| GSE48662 | Down | -0.3537238084 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Isopropyl Alcohol | DB02325 | EXPT01912 | DB04402 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016389 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029129 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26431329 | The identification of the functions of shuttled senescence-associated miRNAs is expected to shed light on the aging process and on how to delay ARD development |
| 26414019 | BACKGROUND: Oral submucous fibrosis (OSMF) is a pre-malignant condition that is strongly associated with the areca nut alkaloids, arecoline (ARC) and arecaidine (ARD) |
| 26414019 | METHODS: Two oral fibroblast lines were treated for 48h with ARC and ARD |
| 26414019 | RESULTS: ARC (100 and 300 muM) and ARD (30 and 100 muM) significantly (P < 0 |
| 22797304 | Postmitotic neurons, such as photoreceptor cells in the retina and epithelial cells in the adjacent retinal pigmented epithelium, are especially susceptible to cellular senescence, which contributes to age-related retinal degeneration (ARD) |
| 22797304 | The multigenic and complex etiology of ARD in humans is reflected by the relative paucity of effective compounds for its early prevention and treatment |
| 22797304 | To understand the genetic differences that drive ARD pathogenesis, we studied A/J mice, which develop ARD more pronounced than that in other inbred mouse models |
| 22797304 | Although our investigation of consomic strains failed to identify a chromosome associated with the observed retinal deterioration, pathway analysis of RNA-Seq data from young mice prior to retinal pathological changes revealed that increased vulnerability to ARD in A/J mice was due to initially high levels of inflammatory factors and low levels of homeostatic neuroprotective factors |
| 22797304 | The genetic signatures of an uncompensated preinflammatory state and ARD progression identified here aid in understanding the susceptible genetic loci that underlie pathogenic mechanisms of age-associated disorders, including several human blinding diseases |
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