HCSGD entry for PPP2R5A
1. General information
| Official gene symbol | PPP2R5A |
|---|---|
| Entrez ID | 5525 |
| Gene full name | protein phosphatase 2, regulatory subunit B', alpha |
| Other gene symbols | B56A PR61A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000159 | Protein phosphatase type 2A complex | IDA | cellular_component |
| GO:0000775 | Chromosome, centromeric region | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0008601 | Protein phosphatase type 2A regulator activity | IEA | molecular_function |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0019900 | Kinase binding | IPI | molecular_function |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0031430 | M band | ISS | cellular_component |
| GO:0035307 | Positive regulation of protein dephosphorylation | IMP | biological_process |
| GO:0090005 | Negative regulation of establishment of protein localization to plasma membrane | IMP | biological_process |
| GO:0090219 | Negative regulation of lipid kinase activity | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6244552563 | 0.3231696554 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0566643337 |
| GSE13712_SHEAR | Down | -0.2735464931 |
| GSE13712_STATIC | Down | -0.3209836971 |
| GSE19018 | Up | 0.0869820169 |
| GSE19899_A1 | Down | -0.2424714108 |
| GSE19899_A2 | Down | -0.1122092162 |
| PubMed_21979375_A1 | Up | 0.6141635058 |
| PubMed_21979375_A2 | Up | 0.0998857056 |
| GSE35957 | Down | -0.0270655675 |
| GSE36640 | Up | 0.0965840691 |
| GSE54402 | Down | -0.0237220091 |
| GSE9593 | Down | -0.0577777941 |
| GSE43922 | Down | -0.0381966275 |
| GSE24585 | Up | 0.3066391083 |
| GSE37065 | Up | 0.0477020022 |
| GSE28863_A1 | Up | 0.2656585426 |
| GSE28863_A2 | Up | 0.4682787301 |
| GSE28863_A3 | Down | -0.5685174974 |
| GSE28863_A4 | Down | -0.2128120749 |
| GSE48662 | Down | -0.3379300526 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT004602 | Luciferase reporter assay//Western blot | Functional MTI | 19131648 |
| hsa-miR-590-3p | MIMAT0004801 | MIRT016181 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018236 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-484 | MIMAT0002174 | MIRT042199 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
