HCSGD entry for APPL2
1. General information
| Official gene symbol | APPL2 |
|---|---|
| Entrez ID | 55198 |
| Gene full name | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 |
| Other gene symbols | DIP13B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IC | cellular_component |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008283 | Cell proliferation | IDA | biological_process |
| GO:0010008 | Endosome membrane | IDA | cellular_component |
| GO:0016581 | NuRD complex | IDA | cellular_component |
| GO:0031901 | Early endosome membrane | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9578047719 | 0.0006243494 | 0.9999902473 | 0.0465538244 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5214534728 |
| GSE13712_SHEAR | Down | -0.8418099658 |
| GSE13712_STATIC | Down | -0.6592746673 |
| GSE19018 | Down | -0.0403969117 |
| GSE19899_A1 | Down | -1.5880399453 |
| GSE19899_A2 | Down | -2.8562348452 |
| PubMed_21979375_A1 | Down | -3.2031619279 |
| PubMed_21979375_A2 | Down | -3.5014070854 |
| GSE35957 | Up | 0.5518570266 |
| GSE36640 | Down | -0.3681207370 |
| GSE54402 | Down | -0.4901643009 |
| GSE9593 | Up | 0.3485435020 |
| GSE43922 | Down | -1.7548799540 |
| GSE24585 | Up | 0.4486917426 |
| GSE37065 | Down | -0.5182604366 |
| GSE28863_A1 | Up | 0.0179489947 |
| GSE28863_A2 | Up | 0.2405688876 |
| GSE28863_A3 | Down | -0.6230232524 |
| GSE28863_A4 | Up | 0.0193228062 |
| GSE48662 | Down | -0.5581287663 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019898 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022951 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
