HCSGD entry for PBRM1
1. General information
| Official gene symbol | PBRM1 |
|---|---|
| Entrez ID | 55193 |
| Gene full name | polybromo 1 |
| Other gene symbols | BAF180 PB1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000228 | Nuclear chromosome | NAS | cellular_component |
| GO:0000776 | Kinetochore | IEA | cellular_component |
| GO:0001890 | Placenta development | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006338 | Chromatin remodeling | TAS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0007067 | Mitosis | TAS | biological_process |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9629955587 | 0.0482792409 | 0.9999902473 | 0.4115048867 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3675622104 |
| GSE13712_SHEAR | Up | 0.0315793398 |
| GSE13712_STATIC | Down | -0.2514975740 |
| GSE19018 | Down | -0.3345399003 |
| GSE19899_A1 | Down | -0.3236334321 |
| GSE19899_A2 | Down | -0.4611563085 |
| PubMed_21979375_A1 | Down | -0.5146210030 |
| PubMed_21979375_A2 | Down | -0.2855791703 |
| GSE35957 | Down | -0.1207666039 |
| GSE36640 | Down | -0.5740687164 |
| GSE54402 | Down | -0.0156520743 |
| GSE9593 | Down | -0.1435970714 |
| GSE43922 | Down | -0.2160243187 |
| GSE24585 | Up | 0.0477760026 |
| GSE37065 | Down | -0.0710472068 |
| GSE28863_A1 | Up | 0.5712888665 |
| GSE28863_A2 | Up | 0.4890217331 |
| GSE28863_A3 | Down | -0.0749273148 |
| GSE28863_A4 | Down | -0.1509017990 |
| GSE48662 | Down | -0.1776105627 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005153 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020793 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020793 | Reporter assay;Other | Non-Functional MTI | 20584899 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028017 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030867 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036263 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036515 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036962 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26992241 | BAF180 (also called PBRM1), a subunit of the SWI/SNF complex, plays critical roles in the regulation of chromatin remodeling and gene transcription, and is frequently mutated in several human cancers |
| 26992241 | However, the role of mammalian BAF180 in tumor suppression and tissue maintenance in vivo remains largely unknown |
| 26992241 | Here, using a conditional somatic knockout approach, we explored the cellular and organismal functions of BAF180 in mouse |
| 26992241 | BAF180 deletion in primary mouse embryonic fibroblasts (MEFs) triggers profound cell cycle arrest, premature cellular senescence, without affecting DNA damage response or chromosomal integrity |
| 26992241 | While somatic deletion of BAF180 in adult mice does not provoke tumor development, BAF180 deficient mice exhibit defects in hematopoietic system characterized by progressive reduction of hematopoietic stem cells (HSCs), defective long-term repopulating potential, and hematopoietic lineage developmental aberrations |
| 26992241 | BAF180 deletion results in elevated p21 expression in both MEFs and HSCs |
| 26992241 | Mechanistically, we showed that BAF180 binds to p21 promoter, and BAF180 deletion enhances the binding of modified histones associated with transcriptional activation on p21 promoter |
| 26992241 | Deletion of p21 rescues cell cycle arrest and premature senescence in BAF180 deficient MEFs, and partially rescues hematopoietic defects in BAF180 deficient mice |
| 26992241 | Together, our study identifies BAF180 as a critical regulator of cellular senescence and HSC homeostasis, which is at least partially regulated through BAF180-mediated suppression of p21 expression |
| 26992241 | Our results also suggest that senescence triggered by BAF180 inactivation may serve as a failsafe mechanism to restrain BAF180 deficiency-associated tumor development, providing a conceptual framework to further understand BAF180 function in tumor biology |
| 20660729 | Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence |
| 20660729 | Here we describe BRD7 and BAF180 as unique regulators of replicative senescence in human cells |
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