HCSGD entry for PPP2CB
1. General information
| Official gene symbol | PPP2CB |
|---|---|
| Entrez ID | 5516 |
| Gene full name | protein phosphatase 2, catalytic subunit, beta isozyme |
| Other gene symbols | PP2Abeta PP2CB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000159 | Protein phosphatase type 2A complex | IEA TAS | cellular_component |
| GO:0000775 | Chromosome, centromeric region | IEA | cellular_component |
| GO:0000922 | Spindle pole | IEA | cellular_component |
| GO:0004721 | Phosphoprotein phosphatase activity | IEA | molecular_function |
| GO:0004722 | Protein serine/threonine phosphatase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006470 | Protein dephosphorylation | IEA TAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IEA | molecular_function |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0008637 | Apoptotic mitochondrial changes | IEA | biological_process |
| GO:0010468 | Regulation of gene expression | IEA | biological_process |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0034976 | Response to endoplasmic reticulum stress | IEA | biological_process |
| GO:0042542 | Response to hydrogen peroxide | IEA | biological_process |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0046580 | Negative regulation of Ras protein signal transduction | IEA | biological_process |
| GO:0046677 | Response to antibiotic | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8584496182 | 0.2988967554 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1211753362 |
| GSE13712_SHEAR | Up | 0.1017807567 |
| GSE13712_STATIC | Up | 0.0468043739 |
| GSE19018 | Down | -0.0266479113 |
| GSE19899_A1 | Down | -0.0506954616 |
| GSE19899_A2 | Up | 0.2811431814 |
| PubMed_21979375_A1 | Down | -0.3830179784 |
| PubMed_21979375_A2 | Down | -0.3634058545 |
| GSE35957 | Up | 0.0528065564 |
| GSE36640 | Up | 0.1493487935 |
| GSE54402 | Down | -0.0847380514 |
| GSE9593 | Up | 0.1615331980 |
| GSE43922 | Down | -0.0067434861 |
| GSE24585 | Down | -0.1239593605 |
| GSE37065 | Down | -0.1068270575 |
| GSE28863_A1 | Up | 0.0409428289 |
| GSE28863_A2 | Up | 0.1775668444 |
| GSE28863_A3 | Down | -0.2583447020 |
| GSE28863_A4 | Up | 0.1065561921 |
| GSE48662 | Down | -0.4711953983 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Vitamin E | DB00163 | NUTR00061 | EXPT03227 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-425-5p | MIMAT0003393 | MIRT016657 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-421 | MIMAT0003339 | MIRT039452 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
