HCSGD entry for DARS2
1. General information
| Official gene symbol | DARS2 |
|---|---|
| Entrez ID | 55157 |
| Gene full name | aspartyl-tRNA synthetase 2, mitochondrial |
| Other gene symbols | ASPRS LBSL MT-ASPRS RP3-383J4.2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000049 | TRNA binding | TAS | molecular_function |
| GO:0004812 | Aminoacyl-tRNA ligase activity | IEA | molecular_function |
| GO:0004815 | Aspartate-tRNA ligase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA TAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA TAS | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006418 | TRNA aminoacylation for protein translation | IEA TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0043039 | TRNA aminoacylation | IDA | biological_process |
| GO:0050560 | Aspartate-tRNA(Asn) ligase activity | IDA | molecular_function |
| GO:0070145 | Mitochondrial asparaginyl-tRNA aminoacylation | IC | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9935099540 | 0.0017583792 | 0.9999902473 | 0.0801524221 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3191074052 |
| GSE13712_SHEAR | Down | -0.2335579598 |
| GSE13712_STATIC | Down | -0.5313567276 |
| GSE19018 | Up | 0.0022190876 |
| GSE19899_A1 | Down | -0.4351438796 |
| GSE19899_A2 | Down | -1.8518614627 |
| PubMed_21979375_A1 | Down | -0.8425648511 |
| PubMed_21979375_A2 | Down | -1.4698743810 |
| GSE35957 | Down | -0.6991071149 |
| GSE36640 | Down | -2.7011945122 |
| GSE54402 | Down | -0.2021702533 |
| GSE9593 | Down | -0.2989518394 |
| GSE43922 | Down | -0.7369105567 |
| GSE24585 | Down | -0.0199689834 |
| GSE37065 | Down | -0.2581585960 |
| GSE28863_A1 | Up | 0.1162883981 |
| GSE28863_A2 | Up | 0.2819063843 |
| GSE28863_A3 | Down | -0.7884509586 |
| GSE28863_A4 | Down | -0.1036028984 |
| GSE48662 | Down | -0.5669644837 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Aspartic Acid | DB00128 | NUTR00016 | EXPT01823 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028622 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045053 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046656 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT050370 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
