HCSGD entry for ANO1
1. General information
| Official gene symbol | ANO1 |
|---|---|
| Entrez ID | 55107 |
| Gene full name | anoctamin 1, calcium activated chloride channel |
| Other gene symbols | DOG1 ORAOV2 TAOS2 TMEM16A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005229 | Intracellular calcium activated chloride channel activity | IDA IMP ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA ISS TAS | cellular_component |
| GO:0006821 | Chloride transport | ISS | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0034707 | Chloride channel complex | IEA | cellular_component |
| GO:0042391 | Regulation of membrane potential | IEA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:1902476 | Chloride transmembrane transport | IDA IMP ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9240843395 | 0.0119812773 | 0.9999902473 | 0.2162957476 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1350349708 |
| GSE13712_SHEAR | Down | -0.5254489774 |
| GSE13712_STATIC | Down | -0.1096012931 |
| GSE19018 | Down | -0.2819077611 |
| GSE19899_A1 | Down | -1.1868163001 |
| GSE19899_A2 | Down | -1.2117385295 |
| PubMed_21979375_A1 | Down | -0.5612776166 |
| PubMed_21979375_A2 | Down | -2.8254181945 |
| GSE35957 | Up | 0.0516091804 |
| GSE36640 | Down | -0.4187340365 |
| GSE54402 | Down | -0.2865305803 |
| GSE9593 | Up | 0.0463496862 |
| GSE43922 | Down | -2.3982553099 |
| GSE24585 | Up | 0.2340807919 |
| GSE37065 | Up | 0.1191085029 |
| GSE28863_A1 | Down | -0.0893369115 |
| GSE28863_A2 | Down | -0.0146429772 |
| GSE28863_A3 | Up | 0.3175543982 |
| GSE28863_A4 | Up | 0.0876910974 |
| GSE48662 | Up | 0.3327019888 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Crofelemer | DB04941 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018614 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022406 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
