HCSGD entry for WIPI1
1. General information
| Official gene symbol | WIPI1 |
|---|---|
| Entrez ID | 55062 |
| Gene full name | WD repeat domain, phosphoinositide interacting 1 |
| Other gene symbols | ATG18 ATG18A WIPI49 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000045 | Autophagic vacuole assembly | IBA | biological_process |
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0000407 | Pre-autophagosomal structure | IDA | cellular_component |
| GO:0000421 | Autophagic vacuole membrane | IDA | cellular_component |
| GO:0005102 | Receptor binding | IDA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005802 | Trans-Golgi network | IDA | cellular_component |
| GO:0005829 | Cytosol | IBA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0006914 | Autophagy | IEP | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0010008 | Endosome membrane | IDA | cellular_component |
| GO:0030136 | Clathrin-coated vesicle | IEA | cellular_component |
| GO:0030331 | Estrogen receptor binding | IDA | molecular_function |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0032266 | Phosphatidylinositol-3-phosphate binding | IDA | molecular_function |
| GO:0034045 | Pre-autophagosomal structure membrane | IDA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0048203 | Vesicle targeting, trans-Golgi to endosome | IDA | biological_process |
| GO:0050681 | Androgen receptor binding | IDA | molecular_function |
| GO:0080025 | Phosphatidylinositol-3,5-bisphosphate binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0045611527 | 0.9868614148 | 0.1782794074 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5694693982 |
| GSE13712_SHEAR | Down | -0.0493601636 |
| GSE13712_STATIC | Down | -0.0280045683 |
| GSE19018 | Up | 0.5584489056 |
| GSE19899_A1 | Up | 0.6777197960 |
| GSE19899_A2 | Up | 0.6638101800 |
| PubMed_21979375_A1 | Down | -0.1317865360 |
| PubMed_21979375_A2 | Up | 0.3073966126 |
| GSE35957 | Up | 0.0656647901 |
| GSE36640 | Up | 1.6561438281 |
| GSE54402 | Up | 0.2508678376 |
| GSE9593 | Up | 0.2680303238 |
| GSE43922 | Up | 0.0964925517 |
| GSE24585 | Up | 1.2478389251 |
| GSE37065 | Up | 0.0854356269 |
| GSE28863_A1 | Up | 0.2257729431 |
| GSE28863_A2 | Up | 0.2927204897 |
| GSE28863_A3 | Down | -0.4537990104 |
| GSE28863_A4 | Up | 0.2476842589 |
| GSE48662 | Up | 0.0726271443 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26091153 | 98-fold); PIM-2 oncogene, a positive regulator of autophagy (3-fold); WIPI49 (linked to starvation-induced autophagy) (upregulated 2 |
| 22606351 | Among the 24 human autophagy-related genes examined, a 12-fold increase of ATG9B at day 4 and a 20-fold increase of ATG18 at day 2 after DOX treatment were noted |
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