HCSGD entry for PPP1CC

1. General information

Official gene symbolPPP1CC
Entrez ID5501
Gene full nameprotein phosphatase 1, catalytic subunit, gamma isozyme
Other gene symbolsPP-1G PP1C PPP1G
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000278Mitotic cell cycleTASbiological_process
GO:0000777Condensed chromosome kinetochoreIEAcellular_component
GO:0004721Phosphoprotein phosphatase activityIEA TASmolecular_function
GO:0004722Protein serine/threonine phosphatase activityIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005741Mitochondrial outer membraneIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005977Glycogen metabolic processIEAbiological_process
GO:0006470Protein dephosphorylationIEAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0016607Nuclear speckIEAcellular_component
GO:0016787Hydrolase activityIEAmolecular_function
GO:0019433Triglyceride catabolic processTASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030182Neuron differentiationIEAbiological_process
GO:0030496MidbodyIEAcellular_component
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0032154Cleavage furrowIEAcellular_component
GO:0043197Dendritic spineIEAcellular_component
GO:0043234Protein complexIMPcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046822Regulation of nucleocytoplasmic transportIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051301Cell divisionIEAbiological_process
GO:0070688MLL5-L complexIDAcellular_component
GO:0072357PTW/PP1 phosphatase complexIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95149341590.02323668550.99999024730.2935466891

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0369334235
GSE13712_SHEARDown-0.3858652689
GSE13712_STATICDown-0.0931303141
GSE19018Down-0.4057294081
GSE19899_A1Down-0.2724319582
GSE19899_A2Down-0.2527502865
PubMed_21979375_A1Down-0.2728246920
PubMed_21979375_A2Down-0.4911392254
GSE35957Down-0.6048522023
GSE36640Down-0.8277330919
GSE54402Up0.1725911866
GSE9593Down-0.2428201166
GSE43922Down-0.1308350417
GSE24585Up0.0561584537
GSE37065Down-0.0855221253
GSE28863_A1Up0.1777744278
GSE28863_A2Up0.3416158752
GSE28863_A3Down-0.7850193537
GSE28863_A4Up0.3426963979
GSE48662Down-0.7584811301

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL406220CHEMBL44388P36873
CHEMBL444092CHEMBL44388P36873
CHEMBL280487CHEMBL44388P36873
CHEMBL444092CHEMBL44388P36873
CHEMBL444092CHEMBL44388P36873
CHEMBL444092CHEMBL44388P36873
CHEMBL280487CHEMBL44388P36873
CHEMBL444092CHEMBL44388P36873
CHEMBL280487CHEMBL44388P36873
CHEMBL280487CHEMBL44388P36873
CHEMBL444092CHEMBL44388P36873
CHEMBL444092CHEMBL44388P36873
CHEMBL444092CHEMBL44388P36873
CHEMBL444092CHEMBL44388P36873
CHEMBL280487CHEMBL44388P36873
CHEMBL280487CHEMBL44388P36873
CHEMBL444092CHEMBL44388P36873
CHEMBL280487CHEMBL44388P36873
CHEMBL48449CHEMBL44388P36873
CHEMBL17154CHEMBL44388P36873
CHEMBL16701CHEMBL44388P36873
CHEMBL17425CHEMBL44388P36873
CHEMBL278014CHEMBL44388P36873
CHEMBL415297CHEMBL44385P36873
CHEMBL505512CHEMBL44385P36873
CHEMBL280487CHEMBL44385P36873
CHEMBL444092CHEMBL44385P36873
CHEMBL17096CHEMBL44385P36873
CHEMBL17073CHEMBL44385P36873
CHEMBL48449CHEMBL44385P36873
CHEMBL275516CHEMBL44385P36873
CHEMBL40248CHEMBL44384P36873
CHEMBL126291CHEMBL44384P36873
CHEMBL1237212CHEMBL44384P36873
CHEMBL200117CHEMBL44384P36873
CHEMBL382338CHEMBL44384P36873
CHEMBL204337CHEMBL44384P36873
CHEMBL129709CHEMBL44384P36873
CHEMBL295239CHEMBL44384P36873
CHEMBL202197CHEMBL44384P36873
CHEMBL99039CHEMBL44384P36873
CHEMBL40942CHEMBL44384P36873
CHEMBL505512CHEMBL44384P36873
CHEMBL505512CHEMBL44384P36873
CHEMBL48449CHEMBL44384P36873
CHEMBL201662CHEMBL44384P36873
CHEMBL40247CHEMBL44384P36873
CHEMBL295238CHEMBL44384P36873
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  • Drugs

Name

Drug

Accession number

9,10-Deepithio-9,10-DidehydroacanthifolicinDB02169 EXPT02429
Calyculin ADB02860 EXPT01080
(2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACIDDB04675 -
MotuporinDB04738 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT028665ProteomicsFunctional MTI (Weak)18668040
hsa-miR-940MIMAT0004983MIRT036628CLASHFunctional MTI (Weak)23622248
hsa-miR-185-5pMIMAT0000455MIRT045316CLASHFunctional MTI (Weak)23622248
hsa-miR-15b-5pMIMAT0000417MIRT046498CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049174CLASHFunctional MTI (Weak)23622248
hsa-miR-26b-5pMIMAT0000083MIRT050049CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050065CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.