HCSGD entry for LAMTOR1

1. General information

Official gene symbolLAMTOR1
Entrez ID55004
Gene full namelate endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Other gene symbolsC11orf59 PDRO Ragulator1 p18 p27RF-Rho
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001919Regulation of receptor recyclingIEA ISSbiological_process
GO:0005085Guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005764LysosomeIDAcellular_component
GO:0005765Lysosomal membraneIEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0007032Endosome organizationISSbiological_process
GO:0007040Lysosome organizationIEA ISSbiological_process
GO:0010872Regulation of cholesterol esterificationIMPbiological_process
GO:0010874Regulation of cholesterol effluxIMPbiological_process
GO:0016049Cell growthIMPbiological_process
GO:0031902Late endosome membraneISScellular_component
GO:0032008Positive regulation of TOR signalingIEA IMPbiological_process
GO:0032418Lysosome localizationISSbiological_process
GO:0032439Endosome localizationIEA ISSbiological_process
GO:0032947Protein complex scaffoldIDAmolecular_function
GO:0034613Cellular protein localizationIMPbiological_process
GO:0042632Cholesterol homeostasisIEA IMPbiological_process
GO:0043087Regulation of GTPase activityIDAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043410Positive regulation of MAPK cascadeIEA ISSbiological_process
GO:0045121Membrane raftISScellular_component
GO:0060620Regulation of cholesterol importIMPbiological_process
GO:0071230Cellular response to amino acid stimulusIEA IMPbiological_process
GO:0071986Ragulator complexIDA IEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66741292120.32405608070.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4445032016
GSE13712_SHEARDown-0.2965455173
GSE13712_STATICDown-0.2539588744
GSE19018Down-0.3518029152
GSE19899_A1Down-0.1270908341
GSE19899_A2Up0.3711510154
PubMed_21979375_A1Up0.3086493448
PubMed_21979375_A2Up0.2398208430
GSE35957Up0.0012927465
GSE36640Up0.0793608592
GSE54402Up0.2908365690
GSE9593Up0.1013185577
GSE43922Down-0.0512519582
GSE24585Down-0.1064393163
GSE37065Down-0.0802447025
GSE28863_A1Down-0.3379367456
GSE28863_A2Up0.0431350929
GSE28863_A3Down-0.3837108223
GSE28863_A4Down-0.0963726326
GSE48662Down-0.0167047439

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT031493ProteomicsFunctional MTI (Weak)18668040
hsa-miR-20a-5pMIMAT0000075MIRT050533CLASHFunctional MTI (Weak)23622248
hsa-let-7c-5pMIMAT0000064MIRT051830CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.