HCSGD entry for PINX1
1. General information
| Official gene symbol | PINX1 |
|---|---|
| Entrez ID | 54984 |
| Gene full name | PIN2/TERF1 interacting, telomerase inhibitor 1 |
| Other gene symbols | LPTL LPTS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000228 | Nuclear chromosome | IDA | cellular_component |
| GO:0000776 | Kinetochore | IDA | cellular_component |
| GO:0000777 | Condensed chromosome kinetochore | IEA | cellular_component |
| GO:0000781 | Chromosome, telomeric region | IEA | cellular_component |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005819 | Spindle | IDA | cellular_component |
| GO:0007004 | Telomere maintenance via telomerase | IEA | biological_process |
| GO:0007080 | Mitotic metaphase plate congression | IMP | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | NAS | biological_process |
| GO:0010521 | Telomerase inhibitor activity | TAS | molecular_function |
| GO:0043086 | Negative regulation of catalytic activity | TAS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0051972 | Regulation of telomerase activity | TAS | biological_process |
| GO:0051974 | Negative regulation of telomerase activity | TAS | biological_process |
| GO:0070034 | Telomeric RNA binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8411930550 | 0.1015382318 | 0.9999902473 | 0.6100405843 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0826313469 |
| GSE13712_SHEAR | Up | 0.0018775427 |
| GSE13712_STATIC | Up | 0.2514352180 |
| GSE19018 | Down | -0.2191042166 |
| GSE19899_A1 | Down | -0.2905382974 |
| GSE19899_A2 | Up | 0.0964376618 |
| PubMed_21979375_A1 | Up | 0.6594895916 |
| PubMed_21979375_A2 | Down | -0.1384892572 |
| GSE35957 | Down | -0.5692446613 |
| GSE36640 | Down | -0.5590083891 |
| GSE54402 | Up | 0.1706711984 |
| GSE9593 | Down | -0.4943827971 |
| GSE43922 | Up | 0.0506308928 |
| GSE24585 | Down | -0.6159151287 |
| GSE37065 | Down | -0.1173674057 |
| GSE28863_A1 | Down | -0.1313910195 |
| GSE28863_A2 | Down | -0.0539228767 |
| GSE28863_A3 | Up | 0.1977449571 |
| GSE28863_A4 | Down | -0.0311126725 |
| GSE48662 | Down | -0.1494261639 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-331-3p | MIMAT0000760 | MIRT043552 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24839934 | PinX1 without the G-patch motif suppresses proliferation, induces senescence, but does not inhibit telomerase activity in colorectal cancer SW480 cells |
| 24839934 | Evidence suggests that Pin2/TRF1-interacting protein X1 (PinX1) inhibits telomerase activity in many types of cancer cells |
| 24839934 | G-patch is a motif in the PinX1 protein; however, the function of G-patch in colorectal cancer cells has not been definitively elucidated |
| 24839934 | The present study investigated the antitumor activities of different PinX1 fragments in vitro, and explored the molecular mechanisms responsible for these effects |
| 24839934 | Flow cytometry was used to observe apoptosis and the cell cycle of SW480 cells transfected with intact PinX1 or truncated PinX1 |
| 24839934 | Our results indicate that both intact and truncated PinX1 induced apoptosis, G1 arrest, and cellular senescence |
| 24839934 | However, truncated PinX1 showed no effects on telomerase activity |
| 24839934 | Why PinX1 without G-patch has similar antitumor activities as intact PinX1 remains unclear |
| 24839934 | Finally, we detected the protein and mRNA levels of PinX1 and caspase 3, 8 and 9 in colorectal cancer specimens and confirmed that levels of PinX1 and caspase 3, 8 and 9 expression were closely linked to the poor prognosis of colorectal cancer |
| 17624691 | Rat homolog of PinX1 is a nucleolar protein involved in the regulation of telomere length |
| 17624691 | Human PinX1 involves in regulation of telomere length |
| 17624691 | Here, we describe the function of a rat homolog of PinX1 |
| 17624691 | Rat PinX1 (rPinX1) was cloned from WB-F344, a rat hepatic stem-like epithelial cell |
| 17624691 | It encodes a protein of 331 amino acids with 70% homology to human PinX1 and 91% homology to mouse |
| 17624691 | However, the telomeric 3' overhang was not altered by PinX1 expression |
| 17624691 | This study demonstrates that a rat homolog of human PinX1 is a nucleolar protein, and that overexpression of rPinX1 induces cellular senescence and telomere shortening, but has no effect on 3' overhang length |
| 17624691 | The function of PinX1 in regulating telomere length is conserved in rodents, and this study may provide insight into the mechanism by which a nucleolar protein can regulate telomere length |
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