HCSGD entry for CLN6
1. General information
| Official gene symbol | CLN6 |
|---|---|
| Entrez ID | 54982 |
| Gene full name | ceroid-lipofuscinosis, neuronal 6, late infantile, variant |
| Other gene symbols | CLN4A HsT18960 nclf |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001573 | Ganglioside metabolic process | IMP | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0007042 | Lysosomal lumen acidification | IMP | biological_process |
| GO:0007601 | Visual perception | IEA | biological_process |
| GO:0008203 | Cholesterol metabolic process | IMP | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0030163 | Protein catabolic process | NAS | biological_process |
| GO:0030203 | Glycosaminoglycan metabolic process | IMP | biological_process |
| GO:0031987 | Locomotion involved in locomotory behavior | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0044265 | Cellular macromolecule catabolic process | IEA | biological_process |
| GO:0045862 | Positive regulation of proteolysis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9577779302 | 0.0921767790 | 0.9999902473 | 0.5780760067 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1119863600 |
| GSE13712_SHEAR | Down | -0.0794714293 |
| GSE13712_STATIC | Up | 0.1183405227 |
| GSE19018 | Down | -0.0514253013 |
| GSE19899_A1 | Down | -0.0217536129 |
| GSE19899_A2 | Down | -0.0519155477 |
| PubMed_21979375_A1 | Up | 0.0021855574 |
| PubMed_21979375_A2 | Down | -0.1210710086 |
| GSE35957 | Down | -0.1644038726 |
| GSE36640 | Down | -0.6704338778 |
| GSE54402 | Down | -0.0664103726 |
| GSE9593 | Up | 0.0675347077 |
| GSE43922 | Down | -0.1271069315 |
| GSE24585 | Down | -0.6946797600 |
| GSE37065 | Down | -0.1454784234 |
| GSE28863_A1 | Down | -0.2955701982 |
| GSE28863_A2 | Up | 0.2076239396 |
| GSE28863_A3 | Up | 0.1832568234 |
| GSE28863_A4 | Up | 0.0739030238 |
| GSE48662 | Down | -0.2253563271 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024862 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026355 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040288 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043180 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044786 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
