HCSGD entry for MKS1
1. General information
| Official gene symbol | MKS1 |
|---|---|
| Entrez ID | 54903 |
| Gene full name | Meckel syndrome, type 1 |
| Other gene symbols | BBS13 MES MKS POC12 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0036038 | TCTN-B9D complex | IEA ISS | cellular_component |
| GO:0036064 | Ciliary basal body | IDA | cellular_component |
| GO:0042384 | Cilium assembly | IEA IMP | biological_process |
| GO:0048754 | Branching morphogenesis of an epithelial tube | IEA | biological_process |
| GO:0060271 | Cilium morphogenesis | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8663893659 | 0.1113754873 | 0.9999902473 | 0.6394347864 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0792723172 |
| GSE13712_SHEAR | Up | 0.1008379757 |
| GSE13712_STATIC | Up | 0.4175756861 |
| GSE19018 | Up | 0.0663963826 |
| GSE19899_A1 | Down | -0.0775356642 |
| GSE19899_A2 | Down | -0.6059155091 |
| PubMed_21979375_A1 | Down | -0.3305446541 |
| PubMed_21979375_A2 | Down | -0.4008771951 |
| GSE35957 | Down | -0.3436906399 |
| GSE36640 | Down | -0.5267323438 |
| GSE54402 | Down | -0.2710505725 |
| GSE9593 | Down | -0.0517591508 |
| GSE43922 | Down | -0.2446924929 |
| GSE24585 | Up | 0.6694103942 |
| GSE37065 | Down | -0.1437452378 |
| GSE28863_A1 | Up | 0.1140466328 |
| GSE28863_A2 | Down | -0.1636584508 |
| GSE28863_A3 | Down | -0.2952085159 |
| GSE28863_A4 | Up | 0.0677971665 |
| GSE48662 | Up | 0.0031614174 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26624981 | Deletion of retrograde response genes decreased the arrest-induced death in such cells, whereas deletion of negative regulator of retrograde signaling MKS1 had the opposite effect |
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