HCSGD entry for PXK

1. General information

Official gene symbolPXK
Entrez ID54899
Gene full namePX domain containing serine/threonine kinase
Other gene symbolsMONaKA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingNASmolecular_function
GO:0003779Actin bindingIEAmolecular_function
GO:0004672Protein kinase activityIEA NASmolecular_function
GO:0005524ATP bindingIEA NASmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDA ISScellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005886Plasma membraneIDA ISScellular_component
GO:0006468Protein phosphorylationNASbiological_process
GO:0006954Inflammatory responseIMPbiological_process
GO:0007154Cell communicationIEAbiological_process
GO:0008022Protein C-terminus bindingIEA ISSmolecular_function
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0032780Negative regulation of ATPase activityIEA ISSbiological_process
GO:0035091Phosphatidylinositol bindingIEA NASmolecular_function
GO:0043271Negative regulation of ion transportIEA ISSbiological_process
GO:0050804Regulation of synaptic transmissionISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92992108580.03808748910.99999024730.3678902018

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0978740991
GSE13712_SHEARDown-0.2889782279
GSE13712_STATICUp0.0180612468
GSE19018Down-0.0275472049
GSE19899_A1Down-0.5428999121
GSE19899_A2Down-0.9031750768
PubMed_21979375_A1Down-0.3755171203
PubMed_21979375_A2Down-0.8444652600
GSE35957Down-0.4512386749
GSE36640Up0.3135412936
GSE54402Down-0.3588777743
GSE9593Up0.0976154040
GSE43922Down-0.6029798794
GSE24585Up0.0500265289
GSE37065Down-0.1564882761
GSE28863_A1Up0.2832943391
GSE28863_A2Up0.2283215322
GSE28863_A3Down-0.4142193928
GSE28863_A4Down-0.1295379718
GSE48662Up0.4455912620

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-744-5pMIMAT0004945MIRT037408CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.