HCSGD entry for PPIB
1. General information
| Official gene symbol | PPIB |
|---|---|
| Entrez ID | 5479 |
| Gene full name | peptidylprolyl isomerase B (cyclophilin B) |
| Other gene symbols | CYP-S1 CYPB OI9 SCYLP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000413 | Protein peptidyl-prolyl isomerization | NAS | biological_process |
| GO:0003755 | Peptidyl-prolyl cis-trans isomerase activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | TAS | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | NAS TAS | cellular_component |
| GO:0006457 | Protein folding | IEA | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0042277 | Peptide binding | IEA | molecular_function |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0051082 | Unfolded protein binding | TAS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6884160746 | 0.3327207629 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1523966757 |
| GSE13712_SHEAR | Up | 0.0153111721 |
| GSE13712_STATIC | Down | -0.1065056523 |
| GSE19018 | Up | 0.1346528727 |
| GSE19899_A1 | Down | -0.0891571118 |
| GSE19899_A2 | Down | -0.1204111153 |
| PubMed_21979375_A1 | Up | 0.7125963977 |
| PubMed_21979375_A2 | Down | -0.5390575973 |
| GSE35957 | Down | -0.2312091592 |
| GSE36640 | Down | -0.0545874508 |
| GSE54402 | Up | 0.0584232818 |
| GSE9593 | Up | 0.0729154705 |
| GSE43922 | Up | 0.0831716814 |
| GSE24585 | Down | -0.2679221972 |
| GSE37065 | Up | 0.0427721636 |
| GSE28863_A1 | Down | -0.1887359243 |
| GSE28863_A2 | Down | -0.2919161254 |
| GSE28863_A3 | Down | -0.0193531549 |
| GSE28863_A4 | Up | 0.1469230823 |
| GSE48662 | Up | 0.1267682447 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 1,4-Dithiothreitol | DB04447 | EXPT01291 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001347 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-301a-3p | MIMAT0000688 | MIRT044215 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049173 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24272483 | Here, we report that cyclophilin B (CypB), a prolyl isomerase residing in the endoplasmic reticulum (ER), provides an essential survival signal in glioblastoma multiforme cells |
| 24272483 | Analysis of gene expression databases revealed that CypB is upregulated in many cases of malignant glioma |
| 24272483 | Mechanistically, depletion or pharmacologic inhibition of CypB caused hyperactivation of the oncogenic RAS-mitogen-activated protein kinase pathway, induction of cellular senescence signals, and death resulting from loss of MYC, mutant p53, Chk1, and Janus-activated kinase/STAT3 signaling |
| 24272483 | Elevated reactive oxygen species, ER expansion, and abnormal unfolded protein responses in CypB-depleted glioblastoma multiforme cells indicated that CypB alleviates oxidative and ER stresses and coordinates stress adaptation responses |
| 24272483 | Enhanced cell survival and sustained expression of multiple oncogenic proteins downstream of CypB may thus contribute to the poor outcome of glioblastoma multiforme tumors |
| 24272483 | Our findings link chaperone-mediated protein folding in the ER to mechanisms underlying oncogenic transformation, and they make CypB an attractive and immediately targetable molecule for glioblastoma multiforme therapy |
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