HCSGD entry for CTSA
1. General information
| Official gene symbol | CTSA |
|---|---|
| Entrez ID | 5476 |
| Gene full name | cathepsin A |
| Other gene symbols | GLB2 GSL NGBE PPCA PPGB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004180 | Carboxypeptidase activity | TAS | molecular_function |
| GO:0004185 | Serine-type carboxypeptidase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005764 | Lysosome | NAS | cellular_component |
| GO:0005783 | Endoplasmic reticulum | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0006687 | Glycosphingolipid metabolic process | TAS | biological_process |
| GO:0006886 | Intracellular protein transport | TAS | biological_process |
| GO:0008047 | Enzyme activator activity | TAS | molecular_function |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0043202 | Lysosomal lumen | TAS | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0102963755 | 0.9797985867 | 0.2583516683 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.7289289133 |
| GSE13712_SHEAR | Down | -0.2792309413 |
| GSE13712_STATIC | Down | -0.0998008193 |
| GSE19018 | Up | 0.6481803240 |
| GSE19899_A1 | Up | 0.2747853660 |
| GSE19899_A2 | Up | 0.5468872078 |
| PubMed_21979375_A1 | Up | 1.2336589799 |
| PubMed_21979375_A2 | Up | 1.0955513102 |
| GSE35957 | Down | -0.1115642495 |
| GSE36640 | Up | 0.9871242995 |
| GSE54402 | Down | -0.3219998534 |
| GSE9593 | Up | 0.7592160811 |
| GSE43922 | Up | 0.0416796017 |
| GSE24585 | Up | 0.2278716783 |
| GSE37065 | Up | 0.0926022351 |
| GSE28863_A1 | Up | 0.2372465714 |
| GSE28863_A2 | Up | 0.2867660811 |
| GSE28863_A3 | Down | -0.0756776801 |
| GSE28863_A4 | Down | -0.0276088658 |
| GSE48662 | Up | 0.3185265792 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020678 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036107 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT041135 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-130a-3p | MIMAT0000425 | MIRT045850 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050564 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050910 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051616 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
