HCSGD entry for XAF1
1. General information
| Official gene symbol | XAF1 |
|---|---|
| Entrez ID | 54739 |
| Gene full name | XIAP associated factor 1 |
| Other gene symbols | BIRC4BP HSXIAPAF1 XIAPAF1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0031333 | Negative regulation of protein complex assembly | IEA | biological_process |
| GO:0035456 | Response to interferon-beta | IDA | biological_process |
| GO:0060337 | Type I interferon signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0813243608 | 0.0862538923 | 0.6013562079 | 0.5579627210 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1149957215 |
| GSE13712_SHEAR | Up | 3.5171097961 |
| GSE13712_STATIC | Up | 2.4009237597 |
| GSE19018 | Down | -0.1224024477 |
| GSE19899_A1 | Up | 0.0024919715 |
| GSE19899_A2 | Down | -0.2645079525 |
| PubMed_21979375_A1 | Down | -0.4085915931 |
| PubMed_21979375_A2 | Down | -0.1573770598 |
| GSE35957 | Down | -1.7317168277 |
| GSE36640 | Up | 0.4995187505 |
| GSE54402 | Down | -0.3526692125 |
| GSE9593 | Up | 0.0291030577 |
| GSE43922 | Down | -0.0618955493 |
| GSE24585 | Up | 0.0852939010 |
| GSE37065 | Up | 0.9123140829 |
| GSE28863_A1 | Down | -0.5845152111 |
| GSE28863_A2 | Down | -0.2046041592 |
| GSE28863_A3 | Down | -0.1231730859 |
| GSE28863_A4 | Down | -0.1354051693 |
| GSE48662 | Up | 0.1475791804 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018358 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26802028 | X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is well known as an antagonist of XIAP-mediated caspase inhibition |
| 26802028 | Although XAF1 serves as a tumor-suppressor gene, the role of XAF1 in cellular senescence remains unclear |
| 26802028 | We found that XAF1 expression was increased by genotoxic agents, such as doxorubicin and ionizing radiation in pulmonary microvascular endothelial cells, consequently leading to premature senescence |
| 26802028 | Conversely, downregulation of XAF1 in premature senescent cells partially overcame endothelial cell senescence |
| 26802028 | XAF1 expression was transcriptionally regulated by Bromodomain 7 (BRD7) |
| 26802028 | XAF1 induction with interferon-gamma (IFN-gamma) treatment was abrogated by BRD7 knockdown, which resulted in blocking interferon-induced senescence |
| 26802028 | In lung cancer cells, XAF1 tumor suppressor activity was decreased by BRD7 knockdown, and inhibition of tumor growth by IFN-gamma did not appear in BRD7-depleted xenograft tumors |
| 26802028 | These data suggest that XAF1 is involved in BRD7-associated senescence and plays an important role in the regulation of endothelial senescence through a p53-dependent pathway |
| 23645206 | In this study, ZNF313 is initially identified as a XIAP-associated factor 1 (XAF1)-interacting protein, which upregulates the stability and proapoptotic effect of XAF1 |
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