HCSGD entry for PPBP
1. General information
| Official gene symbol | PPBP |
|---|---|
| Entrez ID | 5473 |
| Gene full name | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) |
| Other gene symbols | B-TG1 Beta-TG CTAP-III CTAP3 CTAPIII CXCL7 LA-PF4 LDGF MDGF NAP-2 PBP SCYB7 TC1 TC2 TGB TGB1 THBGB THBGB1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0005355 | Glucose transmembrane transporter activity | TAS | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008009 | Chemokine activity | IEA | molecular_function |
| GO:0008083 | Growth factor activity | IEA | molecular_function |
| GO:0015758 | Glucose transport | TAS | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0031093 | Platelet alpha granule lumen | TAS | cellular_component |
| GO:0034219 | Carbohydrate transmembrane transport | TAS | biological_process |
| GO:0035428 | Hexose transmembrane transport | TAS | biological_process |
| GO:0042742 | Defense response to bacterium | IEA | biological_process |
| GO:0051781 | Positive regulation of cell division | IEA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0008402568 | 0.9663296037 | 0.0801318841 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.7581329096 |
| GSE13712_SHEAR | Down | -0.0909813003 |
| GSE13712_STATIC | Down | -0.0305833409 |
| GSE19018 | Up | 0.1309711351 |
| GSE19899_A1 | Up | 1.3304555525 |
| GSE19899_A2 | Up | 4.8712846450 |
| PubMed_21979375_A1 | Up | 4.2083799066 |
| PubMed_21979375_A2 | Up | 3.7069438718 |
| GSE35957 | Down | -1.4085888534 |
| GSE36640 | Up | 0.1901008606 |
| GSE54402 | Up | 4.5558055858 |
| GSE9593 | Down | -0.2937361616 |
| GSE43922 | Up | 0.2920133962 |
| GSE24585 | Up | 0.1508800348 |
| GSE37065 | Up | 0.0727965191 |
| GSE28863_A1 | Up | 0.0711222067 |
| GSE28863_A2 | Up | 0.0854736794 |
| GSE28863_A3 | Up | 0.0221799982 |
| GSE28863_A4 | Up | 0.0238895277 |
| GSE48662 | Down | -0.0312990267 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Ethanesulfonic Acid | DB03635 | EXPT01359 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018016 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25989537 | Leptin and Neutrophil-Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus |
| 25989537 | Blockade of leptin or NAP-2 in MSC cultures abolished SLE serum-induced senescence, while direct addition of these 2 factors could promote senescence in cultures of normal MSCs |
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