HCSGD entry for PPAT

1. General information

Official gene symbolPPAT
Entrez ID5471
Gene full namephosphoribosyl pyrophosphate amidotransferase
Other gene symbolsATASE GPAT PRAT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0001822Kidney developmentIEAbiological_process
GO:0004044Amidophosphoribosyltransferase activityIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006144Purine nucleobase metabolic processTASbiological_process
GO:0006164Purine nucleotide biosynthetic processTASbiological_process
GO:0006189'de novo' IMP biosynthetic processIEAbiological_process
GO:0006543Glutamine catabolic processIEAbiological_process
GO:0007595LactationIEAbiological_process
GO:0008152Metabolic processIEAbiological_process
GO:0009113Purine nucleobase biosynthetic processIEAbiological_process
GO:0009116Nucleoside metabolic processIEAbiological_process
GO:0009168Purine ribonucleoside monophosphate biosynthetic processTASbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0032869Cellular response to insulin stimulusIEAbiological_process
GO:0035690Cellular response to drugIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051289Protein homotetramerizationIEAbiological_process
GO:00515394 iron, 4 sulfur cluster bindingIEAmolecular_function
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
GO:0060135Maternal process involved in female pregnancyIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.40633028760.19491376470.99999024730.8553733167

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1123371499
GSE13712_SHEARUp0.3743226497
GSE13712_STATICUp0.2979713230
GSE19018Down-0.5278506135
GSE19899_A1Up0.1874090380
GSE19899_A2Up0.2375336188
PubMed_21979375_A1Up0.4472252020
PubMed_21979375_A2Up0.0981785503
GSE35957Down-0.7587339155
GSE36640Down-0.7755385055
GSE54402Up0.2690299527
GSE9593Down-0.4956363130
GSE43922Up0.0850783403
GSE24585Down-0.2100861371
GSE37065Down-0.0567014683
GSE28863_A1Down-0.1940917738
GSE28863_A2Down-0.1097741063
GSE28863_A3Up0.3226694131
GSE28863_A4Down-0.1373394001
GSE48662Down-0.4212214072

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MercaptopurineDB01033 APRD01096

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125b-5pMIMAT0000423MIRT005010MicroarrayFunctional MTI (Weak)17891175
hsa-miR-215-5pMIMAT0000272MIRT024474MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026845MicroarrayFunctional MTI (Weak)19074876
hsa-miR-98-5pMIMAT0000096MIRT027826MicroarrayFunctional MTI (Weak)19088304
hsa-miR-26b-5pMIMAT0000083MIRT030142MicroarrayFunctional MTI (Weak)19088304
hsa-miR-425-5pMIMAT0003393MIRT039332CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.