HCSGD entry for PDP1

1. General information

Official gene symbolPDP1
Entrez ID54704
Gene full namepyruvate dehyrogenase phosphatase catalytic subunit 1
Other gene symbolsPDH PDP PDPC PPM2C
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004722Protein serine/threonine phosphatase activityIDA IEAmolecular_function
GO:0004741[pyruvate dehydrogenase (lipoamide)] phosphatase activityIEAmolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0006090Pyruvate metabolic processTASbiological_process
GO:0006470Protein dephosphorylationIEAbiological_process
GO:0010510Regulation of acetyl-CoA biosynthetic process from pyruvateTASbiological_process
GO:0035970Peptidyl-threonine dephosphorylationIDAbiological_process
GO:0044237Cellular metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04860442230.42532547400.48642702091.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.9936476141
GSE13712_SHEARUp0.7487539345
GSE13712_STATICUp0.5023492056
GSE19018Down-0.0074146861
GSE19899_A1Up0.2059164248
GSE19899_A2Up0.2169179809
PubMed_21979375_A1Up0.0583143997
PubMed_21979375_A2Up0.8020406741
GSE35957Up0.4174020794
GSE36640Down-0.5786580246
GSE54402Up0.2106999046
GSE9593Up0.5202512451
GSE43922Down-0.0304144626
GSE24585Down-0.4279734100
GSE37065Up0.0714484936
GSE28863_A1Down-0.2865542059
GSE28863_A2Up0.4691622161
GSE28863_A3Down-0.8343084158
GSE28863_A4Down-0.1458770811
GSE48662Down-0.2139265143

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018451MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23685455Here we show, by metabolic profiling and functional perturbations, that the mitochondrial gatekeeper pyruvate dehydrogenase (PDH) is a crucial mediator of senescence induced by BRAF(V600E), an oncogene commonly mutated in melanoma and other cancers
23685455BRAF(V600E)-induced senescence was accompanied by simultaneous suppression of the PDH-inhibitory enzyme pyruvate dehydrogenase kinase 1 (PDK1) and induction of the PDH-activating enzyme pyruvate dehydrogenase phosphatase 2 (PDP2)
23685455The resulting combined activation of PDH enhanced the use of pyruvate in the tricarboxylic acid cycle, causing increased respiration and redox stress
23685455Further supporting a crucial role of PDH in OIS, enforced normalization of either PDK1 or PDP2 expression levels inhibited PDH and abrogated OIS, thereby licensing BRAF(V600E)-driven melanoma development
19403001Moreover, the mRNA and protein expression levels of pyruvate dehydrogenase (PDH) were decreased but those of PDH kinase and lactate dehydrogenase were increased in senescent skin fibroblasts
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