HCSGD entry for MED1

1. General information

Official gene symbolMED1
Entrez ID5469
Gene full namemediator complex subunit 1
Other gene symbolsCRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000785ChromatinIEAcellular_component
GO:0000902Cell morphogenesisIMPbiological_process
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEAmolecular_function
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityISSmolecular_function
GO:0001047Core promoter bindingIDAmolecular_function
GO:0001104RNA polymerase II transcription cofactor activityIDA IEAmolecular_function
GO:0001525AngiogenesisISSbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0001892Embryonic placenta developmentIEAbiological_process
GO:0002088Lens development in camera-type eyeISSbiological_process
GO:0002154Thyroid hormone mediated signaling pathwayIMPbiological_process
GO:0003222Ventricular trabecula myocardium morphogenesisIEAbiological_process
GO:0003406Retinal pigment epithelium developmentIEAbiological_process
GO:0003682Chromatin bindingIMPmolecular_function
GO:0003712Transcription cofactor activityIDAmolecular_function
GO:0003713Transcription coactivator activityIDA IMPmolecular_function
GO:0004872Receptor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006260DNA replicationIEAbiological_process
GO:0006356Regulation of transcription from RNA polymerase I promoterIDAbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterIDA TASbiological_process
GO:0006590Thyroid hormone generationIEAbiological_process
GO:0006702Androgen biosynthetic processIMPbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0007595LactationIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0010628Positive regulation of gene expressionIDA IMPbiological_process
GO:0010839Negative regulation of keratinocyte proliferationIMPbiological_process
GO:0016592Mediator complexIDA IEA IMPcellular_component
GO:0016922Ligand-dependent nuclear receptor bindingIDA IPImolecular_function
GO:0030216Keratinocyte differentiationIMPbiological_process
GO:0030224Monocyte differentiationIEAbiological_process
GO:0030331Estrogen receptor bindingIPImolecular_function
GO:0030374Ligand-dependent nuclear receptor transcription coactivator activityIMP NASmolecular_function
GO:0030375Thyroid hormone receptor coactivator activityIMPmolecular_function
GO:0030518Intracellular steroid hormone receptor signaling pathwayIDAbiological_process
GO:0030521Androgen receptor signaling pathwayIDAbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0031490Chromatin DNA bindingIEAmolecular_function
GO:0032993Protein-DNA complexIEAcellular_component
GO:0033148Positive regulation of intracellular estrogen receptor signaling pathwayIEAbiological_process
GO:0033160Positive regulation of protein import into nucleus, translocationIEAbiological_process
GO:0033601Positive regulation of mammary gland epithelial cell proliferationIEAbiological_process
GO:0035050Embryonic heart tube developmentIEAbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0035162Embryonic hemopoiesisIEAbiological_process
GO:0035357Peroxisome proliferator activated receptor signaling pathwayIEAbiological_process
GO:0035729Cellular response to hepatocyte growth factor stimulusIEAbiological_process
GO:0035855Megakaryocyte developmentISSbiological_process
GO:0036033Mediator complex bindingIDAmolecular_function
GO:0042789MRNA transcription from RNA polymerase II promoterISSbiological_process
GO:0042809Vitamin D receptor bindingIPI NAS TASmolecular_function
GO:0042974Retinoic acid receptor bindingIPImolecular_function
GO:0042975Peroxisome proliferator activated receptor bindingIPImolecular_function
GO:0043066Negative regulation of apoptotic processISSbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045444Fat cell differentiationIDAbiological_process
GO:0045618Positive regulation of keratinocyte differentiationIMPbiological_process
GO:0045665Negative regulation of neuron differentiationISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0046966Thyroid hormone receptor bindingIDA IPImolecular_function
GO:0048821Erythrocyte developmentISSbiological_process
GO:0048822Enucleate erythrocyte developmentIEAbiological_process
GO:0050693LBD domain bindingIPImolecular_function
GO:0051726Regulation of cell cycleNASbiological_process
GO:0060335Positive regulation of interferon-gamma-mediated signaling pathwayIEAbiological_process
GO:0060744Mammary gland branching involved in thelarcheIEAbiological_process
GO:0060745Mammary gland branching involved in pregnancyIEAbiological_process
GO:0060750Epithelial cell proliferation involved in mammary gland duct elongationIEAbiological_process
GO:0070318Positive regulation of G0 to G1 transitionIEAbiological_process
GO:0070371ERK1 and ERK2 cascadeIDAbiological_process
GO:0070562Regulation of vitamin D receptor signaling pathwayIEAbiological_process
GO:0071364Cellular response to epidermal growth factor stimulusIDAbiological_process
GO:0071383Cellular response to steroid hormone stimulusIDAbiological_process
GO:0097067Cellular response to thyroid hormone stimulusIDAbiological_process
GO:2000273Positive regulation of receptor activityIMPbiological_process
GO:2000347Positive regulation of hepatocyte proliferationIEAbiological_process
GO:2001141Regulation of RNA biosynthetic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18318324150.72473949320.83707744791.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0529603223
GSE13712_SHEARDown-0.0510553158
GSE13712_STATICDown-0.1288746364
GSE19018Down-0.2233228676
GSE19899_A1Up0.4269087806
GSE19899_A2Up0.0938709616
PubMed_21979375_A1Up0.4409469140
PubMed_21979375_A2Up0.3212012836
GSE35957Down-0.1522233010
GSE36640Down-0.8187118665
GSE54402Up0.3912374481
GSE9593Down-0.0729572830
GSE43922Up0.1837290990
GSE24585Up0.0776521352
GSE37065Up0.0485503696
GSE28863_A1Up0.5274193040
GSE28863_A2Up0.2454290613
GSE28863_A3Down-0.4963680789
GSE28863_A4Up0.0047211376
GSE48662Down-0.0562285035

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

5-{2-[1-(1-METHYL-PROPYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-2-METHYLENE-CYCLOHEXANE-1,3-DIOLDB08696 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-205-5pMIMAT0000266MIRT003239Luciferase reporter assay//Western blotFunctional MTI20065103
hsa-miR-96-5pMIMAT0000095MIRT027932SequencingFunctional MTI (Weak)20371350
hsa-miR-125b-5pMIMAT0000423MIRT046058CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047640CLASHFunctional MTI (Weak)23622248
hsa-miR-30c-5pMIMAT0000244MIRT047844CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.