HCSGD entry for PPARD

1. General information

Official gene symbolPPARD
Entrez ID5467
Gene full nameperoxisome proliferator-activated receptor delta
Other gene symbolsFAAR NR1C2 NUC1 NUCI NUCII PPARB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0003677DNA bindingISSmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA NASmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0003713Transcription coactivator activityIEAmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityIDA IEAmolecular_function
GO:0005504Fatty acid bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA NAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006006Glucose metabolic processNASbiological_process
GO:0006029Proteoglycan metabolic processIEAbiological_process
GO:0006091Generation of precursor metabolites and energyTASbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006629Lipid metabolic processISSbiological_process
GO:0006635Fatty acid beta-oxidationIEA ISS TASbiological_process
GO:0006776Vitamin A metabolic processIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0007566Embryo implantationIEA TASbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0008203Cholesterol metabolic processTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008283Cell proliferationISS TASbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008289Lipid bindingIDAmolecular_function
GO:0008366Axon ensheathmentIEA ISSbiological_process
GO:0008654Phospholipid biosynthetic processIEAbiological_process
GO:0009062Fatty acid catabolic processTASbiological_process
GO:0009299MRNA transcriptionIEAbiological_process
GO:0009749Response to glucoseIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIEAbiological_process
GO:0014823Response to activityIEAbiological_process
GO:0014912Negative regulation of smooth muscle cell migrationIEAbiological_process
GO:0015758Glucose transportNASbiological_process
GO:0015908Fatty acid transportIEA ISSbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0030308Negative regulation of cell growthIEAbiological_process
GO:0030522Intracellular receptor signaling pathwayIDAbiological_process
GO:0031589Cell-substrate adhesionIEAbiological_process
GO:0032024Positive regulation of insulin secretionIEAbiological_process
GO:0032966Negative regulation of collagen biosynthetic processIEAbiological_process
GO:0033189Response to vitamin AIEAbiological_process
GO:0042060Wound healingIEAbiological_process
GO:0042640AnagenIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0043616Keratinocyte proliferationIEAbiological_process
GO:0045598Regulation of fat cell differentiationIEAbiological_process
GO:0045600Positive regulation of fat cell differentiationNASbiological_process
GO:0045684Positive regulation of epidermis developmentIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045909Positive regulation of vasodilationIEAbiological_process
GO:0046697DecidualizationIEA TASbiological_process
GO:0048662Negative regulation of smooth muscle cell proliferationIEAbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0050728Negative regulation of inflammatory responseIEAbiological_process
GO:0051059NF-kappaB bindingIEAmolecular_function
GO:0051546Keratinocyte migrationIEAbiological_process
GO:0060612Adipose tissue developmentIEAbiological_process
GO:0070539Linoleic acid bindingIDAmolecular_function
GO:0097190Apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41375916190.40777320770.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0435749285
GSE13712_SHEARDown-0.1438131556
GSE13712_STATICDown-0.1349036909
GSE19018Down-0.2265540375
GSE19899_A1Up0.0901030131
GSE19899_A2Up0.7022354165
PubMed_21979375_A1Up0.9446755514
PubMed_21979375_A2Up0.1681508978
GSE35957Down-0.1876102143
GSE36640Down-0.1696340259
GSE54402Up0.8986477659
GSE9593Down-0.0950617600
GSE43922Down-0.2034850935
GSE24585Up0.1190801986
GSE37065Down-0.1468571653
GSE28863_A1Down-0.1420025981
GSE28863_A2Down-0.0227086013
GSE28863_A3Down-0.2538397792
GSE28863_A4Down-0.2075577578
GSE48662Up0.2363623715

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

BezafibrateDB01393 DB08380
Heptyl-Beta-D-GlucopyranosideDB03338 EXPT00614
(11E)-OCTADEC-11-ENOIC ACIDDB04801 -
GFT505DB05187 -
KD3010DB05188 -
(2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acidDB07070 -
2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acidDB07691 -
3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acidDB07724 -
{4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acidDB08078 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-331-3pMIMAT0000760MIRT043275CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049777CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.