HCSGD entry for PPARA
1. General information
| Official gene symbol | PPARA |
|---|---|
| Entrez ID | 5465 |
| Gene full name | peroxisome proliferator-activated receptor alpha |
| Other gene symbols | NR1C1 PPAR PPARalpha hPPAR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0001103 | RNA polymerase II repressing transcription factor binding | IPI | molecular_function |
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA ISS | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IDA | molecular_function |
| GO:0004872 | Receptor activity | IEA | molecular_function |
| GO:0004879 | Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006629 | Lipid metabolic process | TAS | biological_process |
| GO:0006631 | Fatty acid metabolic process | IEA | biological_process |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0008144 | Drug binding | IDA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008289 | Lipid binding | IDA IEA | molecular_function |
| GO:0008544 | Epidermis development | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010745 | Negative regulation of macrophage derived foam cell differentiation | IC IDA | biological_process |
| GO:0010871 | Negative regulation of receptor biosynthetic process | IDA | biological_process |
| GO:0010887 | Negative regulation of cholesterol storage | IDA | biological_process |
| GO:0010891 | Negative regulation of sequestering of triglyceride | IDA | biological_process |
| GO:0015908 | Fatty acid transport | TAS | biological_process |
| GO:0019902 | Phosphatase binding | IEA | molecular_function |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0030522 | Intracellular receptor signaling pathway | IDA | biological_process |
| GO:0031624 | Ubiquitin conjugating enzyme binding | IPI | molecular_function |
| GO:0032000 | Positive regulation of fatty acid beta-oxidation | TAS | biological_process |
| GO:0032091 | Negative regulation of protein binding | IEA | biological_process |
| GO:0032099 | Negative regulation of appetite | IEA ISS | biological_process |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0032868 | Response to insulin | IEA | biological_process |
| GO:0035095 | Behavioral response to nicotine | IEA | biological_process |
| GO:0042060 | Wound healing | IEA | biological_process |
| GO:0042157 | Lipoprotein metabolic process | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA ISS | molecular_function |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045776 | Negative regulation of blood pressure | IEA | biological_process |
| GO:0045820 | Negative regulation of glycolysis | IC | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IEA | biological_process |
| GO:0046321 | Positive regulation of fatty acid oxidation | IEA ISS | biological_process |
| GO:0051525 | NFAT protein binding | IEA | molecular_function |
| GO:0070166 | Enamel mineralization | IEA | biological_process |
| GO:0072363 | Regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0072366 | Regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0072369 | Regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0097371 | MDM2/MDM4 family protein binding | IEA | molecular_function |
| GO:1901215 | Negative regulation of neuron death | IEA | biological_process |
| GO:2000678 | Negative regulation of transcription regulatory region DNA binding | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3639381141 | 0.4154967934 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0388743815 |
| GSE13712_SHEAR | Down | -0.4020158762 |
| GSE13712_STATIC | Down | -0.1592419514 |
| GSE19018 | Up | 0.2191672408 |
| GSE19899_A1 | Down | -0.0715908416 |
| GSE19899_A2 | Down | -0.1983755612 |
| PubMed_21979375_A1 | Down | -0.2754062760 |
| PubMed_21979375_A2 | Down | -0.3088002129 |
| GSE35957 | Down | -0.1765692980 |
| GSE36640 | Down | -0.0347648913 |
| GSE54402 | Up | 0.1163983956 |
| GSE9593 | Up | 0.1628187377 |
| GSE43922 | Down | -0.1180873727 |
| GSE24585 | Up | 0.2205795813 |
| GSE37065 | Down | -0.0452380805 |
| GSE28863_A1 | Up | 1.0734767460 |
| GSE28863_A2 | Up | 0.7285452751 |
| GSE28863_A3 | Down | -0.2398197253 |
| GSE28863_A4 | Up | 0.0242942569 |
| GSE48662 | Down | -0.0169556188 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Indomethacin | DB00328 | APRD00109 |
| Gemfibrozil | DB01241 | APRD00293 |
| Bezafibrate | DB01393 | DB08380 |
| Dehydroepiandrosterone | DB01708 | EXPT00519 | DB06593 |
| N,N-bis(3-(D-gluconamido)propyl)deoxycholamide | DB01890 | EXPT01003 |
| Reglixane | DB04971 | - |
| GFT505 | DB05187 | - |
| 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID | DB07215 | - |
| 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid | DB07724 | - |
| Aleglitazar | DB08915 | DB08483 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-519d-3p | MIMAT0002853 | MIRT000630 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20057369 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT002473 | Western blot | Functional MTI | 18347104 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT002473 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19011694 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT005068 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19780876 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT006422 | Luciferase reporter assay//Flow//Immunoprecipitaion//In situ hybridization//qRT-PCR//Western blot | Functional MTI | 21636785 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT006422 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-141-3p | MIMAT0000432 | MIRT006709 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22479552 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017974 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022715 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-22-3p | MIMAT0000077 | NA | hsa-miR-22 | {Western blot} | {underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 18347104 | |
| hsa-miR-22-3p | MIMAT0000077 | NA | hsa-miR-22 | {Western blot} | {overexpression} | 19011694 | |
| hsa-miR-21-5p | MIMAT0000076 | 1 | hsa-miR-21 | {Western blot} | {overexpression by miRNA precursor transfection} | 20693317 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23000914 | In addition, activation of PPARdelta, but not PPARalpha or PPARgamma, significantly enhanced SIRT1 promoter activity and protein expression |
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