HCSGD entry for ATRX
1. General information
| Official gene symbol | ATRX |
|---|---|
| Entrez ID | 546 |
| Gene full name | alpha thalassemia/mental retardation syndrome X-linked |
| Other gene symbols | ATR2 JMS MRXHF1 RAD54 RAD54L SFM1 SHS XH2 XNP ZNF-HX |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003678 | DNA helicase activity | TAS | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0004386 | Helicase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005720 | Nuclear heterochromatin | TAS | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006306 | DNA methylation | TAS | biological_process |
| GO:0006310 | DNA recombination | TAS | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0030900 | Forebrain development | IEA | biological_process |
| GO:0032508 | DNA duplex unwinding | TAS | biological_process |
| GO:0070087 | Chromo shadow domain binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0856725010 | 0.8030955777 | 0.6141283769 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1985725227 |
| GSE13712_SHEAR | Up | 0.1358495887 |
| GSE13712_STATIC | Up | 0.0828809218 |
| GSE19018 | Up | 0.4566042790 |
| GSE19899_A1 | Up | 0.1470431387 |
| GSE19899_A2 | Down | -0.5556621610 |
| PubMed_21979375_A1 | Up | 0.0547535536 |
| PubMed_21979375_A2 | Up | 0.0314472457 |
| GSE35957 | Up | 0.4923897689 |
| GSE36640 | Up | 0.5331691701 |
| GSE54402 | Down | -0.1436565173 |
| GSE9593 | Up | 0.1441186075 |
| GSE43922 | Down | -0.2328356437 |
| GSE24585 | Up | 0.3744184380 |
| GSE37065 | Up | 0.2067100517 |
| GSE28863_A1 | Up | 0.3310524122 |
| GSE28863_A2 | Up | 0.1578169143 |
| GSE28863_A3 | Down | -0.0927853507 |
| GSE28863_A4 | Up | 0.0235713046 |
| GSE48662 | Up | 0.3238296020 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005165 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030808 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-342-5p | MIMAT0004694 | MIRT038203 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040139 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043383 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050897 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25092303 | This induction coincides with a loss of the cancer-associated ATRX/Daxx-histone H3 |
| 23719597 | In primary PSC, doxorubicin treatment was associated with increased expression of interleukin-6 (IL-6) and matrix metalloproteinase (MMP)-9, while expression of the activation marker alpha-smooth muscle actin (alpha-SMA), p53, Cdk1 and Rad54 was diminished |
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